Journal of Oncology / 2012 / Article / Tab 2

Review Article

The Role of PTEN in Tumor Angiogenesis

Table 2

Clinical trials having shown an impact of the PTEN status on the response to cancer treatment.

Type of cancerMetastatic formTreatmentsReferences

ColorectalCetuximab, panitumab[6669]
×Cetuximab (+irinotecan)[7072]

BreastTrastuzumab, lapatinib[7376]
× Trastuzumab[7678]
Endocrine therapy

GlioblastomaGefitinib, erlotinib [7981]
Erlotinib + temozolomid

GastricStreptozotocin, doxorubicin, 5-fluorouracil, etoposide/cisplatinum[82, 83]
×Streptozotocin, doxorubicin[82]

LungGefitinib, erlotinib[84, 85]
×Gefitinib, erlotinib[85]


Esophageal5-fluoropyrimidine, taxane, platinum, PI3K pathway inhibitor[86]

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