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Journal of Oncology
Volume 2012 (2012), Article ID 146943, 7 pages
Research Article

Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT

1Medical Physics Graduate Program, Duke University, Durham, NC 27710, USA
2Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
3Duke University Medical School, Durham, NC 27710, USA
4Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA

Received 20 May 2012; Accepted 14 June 2012

Academic Editor: Alvaro Ruibal

Copyright © 2012 Steve D. Mann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies were consented and imaged as part of this IRB-approved breast imaging study. For each of the seven subjects, one randomly selected breast was imaged prone-pendant using the dedicated, compact breast SPECT-CT system underneath the shielded patient support. Iteratively reconstructed and attenuation and/or scatter corrected images were coregistered; CT images were segmented into glandular and fatty tissue by three different methods; the average concentration of Sestamibi was determined from the SPECT data using the CT-based segmentation and previously established quantification techniques. Very minor differences between the segmentation methods were observed, and the results indicate an average image-based in vivo Sestamibi concentration of 0.10±0.16μCi/mL with no preferential uptake by glandular or fatty tissues.