Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT

Figure 4

Flowchart diagraming the three segmentation procedures. Each of the three methods uses a dual-Gaussian function to fit the histograms, but the method for choosing an appropriate threshold varies. The simplest method involves choosing the minimum of the total histogram, while more complex methods involve analyzing the percent contribution of each tissue type within the threshold bounds.