Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1
Figure 1
Time course of tumor growth of CT26.WT-GFP tumors in the dorsal skinfold chamber. Stereomicroscopy photographs of representative 14 days old tumors after either treatment with an isotype-matched control antibody (a), pretreatment with anti-c-Kit (b) alone, or pretreatment with anti-c-Kit followed by anti-SDF-1 treatment (c). Quantitative analysis of the tumor area (d) displayed progressive tumor growth in all groups. After anti-c-Kit pretreatment (grey triangles), tumor growth was significantly accelerated compared to controls (white circles). Of interest, additional neutralization of SDF-1 (black squares) completely blunted this anti-c-Kit-associated enhancement of tumor growth. Mean ± SEM; * versus control; # versus anti-c-Kit. Original magnification (a)–(c) ×4.
