Protection against Cancer with Medicinal Herbs via Activation of Tumor Suppressor

Figure 2

Schematic structures of p53, Rb, and PTEN proteins. The predicted consensual domain structures for each protein are depicted. The functionally important sites are also shown. Note that the sizes of protein are modified for clarity. TA: transactivation domain; PxxP: proline-rich region; pocket A, pocket B: a tandem of folds; C2 domain: a protein structural domain involved in targeting proteins to cell membranes; PDZ: a common structural domain in signaling proteins (PSD95, Dlg, ZO-1, etc.).