Journal of Oncology

Clinical Study

Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients

Table 4

Median (25th, 75th quartile) fatty acid concentrations (weight%) in normal duodenal mucosa and tumour biopsies in colorectal cancer patients ( ).
 Normal mucosa (weight%)Tumour tissue (weight%)P value
16:0 (palmitic acid)20.0 (18.6, 21.6)18.3 (17.9, 19.6)0.001
18:0 (stearic acid)8.1 (5.9, 10.3)12.5 (11.0, 13.4)<0.001
16:1 -7 (palmitoleic acid)3.2 (1.9, 4.6)1.8 (1.4, 2.5)0.007
18:1 -9 (oleic acid)33.6 (29.2, 39.6)23.1 (21.2, 24.8)<0.001
18:2 -6 (linoleic acid) (LA)13.5 (12.1, 15.5)12.2 (10.8, 13.4)0.001
18:3 -3 ( -linolenic acid (ALA)0.59 (0.43, 0.76)0.25 (0.15, 0.29)<0.001
20:4 -6 (arachidonic acid) (AA)3.5 (1.8, 6.4)7.5 (6.1, 8.2)0.001
20:5 -3 (eicosapentaenoic acid) (EPA)0.23 (0.17, 0.52)0.57 (0.32, 0.85)0.001
22:6 -3 (docosahexaenoic acid) (DHA)1.30 (0.93, 1.59)2.15 (1.67, 2.64)<0.001
Sum EPA + DHA1.5 (1.1, 2.1)2.7 (2.1, 3.4)<0.001
Ratio AA/EPA9.7 (7.9, 17.3)12.5 (8.5, 20.1)0.03
Sum -3 fatty acids (ALA + EPA + DHA)2.2 (1.8, 2.7)2.9 (2.3, 3.6)<0.001
Sum -6 fatty acids (LA + AA)16.7 (15.2, 21.1)19.8 (17.2, 20.5)0.11
Ratio -3/ -6 fatty acids0.13 (0.11, 0.15)0.15 (0.12, 0.18)<0.001
Sum polyunsaturated fatty acids18.5 (17.2, 23.6)23.0 (19.3, 24.4)0.05