Tumor Angiogenesis: Pericytes and Maturation Are Not to Be Ignored
Negative regulation of angiogenesis by the PlGF-VEGFR1-mediated signaling pathway. In PlGF-producing mouse Lewis lung and human tumors, the tumor vasculature that is induced by PlGF-1 and -2 is covered by pericytes and is less leaky compared to the tumor vasculature that is induced by VEGF-A. This result might be caused by the formation of angiogenically inactive PlGF-VEGF heterodimers .
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