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Journal of Oncology
Volume 2012, Article ID 345164, 7 pages
Review Article

Regulatory T Cells in Human Ovarian Cancer

1Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
2Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA
3Graduate Programs in Immunology and Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA
4University of Michigan School of Medicine, C560B MSRB II, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-0669, USA

Received 15 September 2011; Accepted 26 November 2011

Academic Editor: Kentaro Nakayama

Copyright © 2012 Dong-Jun Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiple layers of suppressive components including regulatory T (TReg) cells, suppressive antigen-presenting cells, and inhibitory cytokines form suppressive networks in the ovarian cancer microenvironment. It has been demonstrated that as a major suppressive element, TReg cells infiltrate tumor, interact with several types of immune cells, and mediate immune suppression through different molecular and cellular mechanisms. In this paper, we focus on human ovarian cancer and will discuss the nature of TReg cells including their subsets, trafficking, expansion, and function. We will briefly review the development of manipulation of TReg cells in preclinical and clinical settings.