Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Table 1

Patient characteristics.

Characteristics	Definitive RT		Postoperative RT
	𝑛	%	𝑛	%
Gender
Female	17	10.5	19	15.1
Male	145	89.5	107	84.9
Age (years)
≤56	87	53.7	72	57.1
>56	75	46.3	54	42.9
Hemoglobin level pre-RT (g/dL)
≤12	27	17.6	46	42.6
>12	126	82.4	62	57.4
Tumor site
Oropharynx	95	58.6	68	54.0
Hypopharynx	67	41.4	58	46.0
cT-Classification^#
1, 2	13	8.1	66	52.4
3, 4	148	91.9	60	47.6
cN-Classification^#
0, 1	14	3.7	50	39.7
2, 3	148	91.3	76	60.3
Stage
≤3	4	3.1	42	33.3
4	157	96.9	84	66.7
Total tumor volume
≤median*	52	43.0	52	46.8
>median*	69	57.0	59	53.2
R-Classification
0	—	—	78	65.0
1	—	—	37	30.8
2	—	—	5	4.2
Fractionation regimen
Conventional	24	14.8	126	100.0
Concomitant boost	138	85.2	0	0.0
Simultaneous radiochemotherapy
Yes	99	61.1	0	0.0
No	63	38.9	126	100.0
RT interruptions >5 days
Yes	36	22.2	24	20.0
No	126	77.8	96	80.0
Interval surgery-RT >32 days
Yes	—	—	58	47.5
No	—	—	64	52.5

RT, radiation therapy; *median for definitive RT is 69.4 cm³, median for postoperative RT is 21.2 cm³.