Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Table 3

Definitive radiation therapy: multivariate analysis of overall survival, locoregional control, and metastasis-free survival.

Factor	Overall survival		Locoregional control		Metastasis-free survival
	RR	𝑃	RR	𝑃	RR	𝑃
Gender	1.34 (95% CI 0.62–2.91)	0.46	1.50 (95% CI 0.70–3.24)	0.30	0.79 (95% CI 0.15–4.07)	0.78
Age	1 (95% CI 0.63–1.59)	0.99	1.20 (95% CI 0.74–1.95)	0.45	0.96 (95% CI 0.47–1.98)	0.91
Hemoglobin level pre-RT	0.74 (95% CI 0.41–1.35)	0.33	0.74 (95% CI 0.42–1.31)	0.30	2.79 (95% CI 0.82–9.46)	0.10
Tumor site	1.24 (95% CI 0.76–2.04)	0.39	1.35 (95% CI 0.81–2.25)	0.24	1.40 (95% CI 0.62–3.15)	0.41
T-Classification	1.17 (95% CI 0.43–3.13)	0.76	0.75 (95% CI 0.22–2.58)	0.65	1.44 (95% CI 0.29–7.12)	0.66
N-Classification	1.14 (95% CI 0.38–3.43)	0.82	5.84 (95% CI 0.88–38.9)	0.07	2.28 (95% CI 0.21–25.1)	0.50
Total tumor volume	2.46 (95% CI 1.47–4.11)	<0.01	2.50 (95% CI 1.43–4.36)	<0.01	1.59 (95% CI 0.78–3.26)	0.20
Simultaneous radiochemotherapy	0.52 (95% CI 0.31–0.88)	0.01	0.68 (95% CI 0.40–1.16)	0.15	2.63 (95% CI 1.03–6.73)	0.04
RT interruptions >5 days	0.95 (95% CI 0.5–1.8)	0.88	0.77 (95% CI 0.36–1.66)	0.51	1.08 (95% CI 0.39–3.04)	0.88

RT, radiation therapy; RR, relative risk, 𝑃: 𝑃-value.