|
Factor | Overall survival | Locoregional failure | Metastasis |
5y-survival | | 5y-CIF | | 5y-CIF | |
|
Gender | | | | | | |
βFemale | 0.89 (95% CI 0.75β1.03) | β | 0.53 (95% CI 0.10β0.85) | β | 0.11 (95% CI 0.02β0.29) | |
βMale | 0.66 (95% CI 0.54β0.77) | 0.17 | 0.33 (95% CI 0.23β0.44) | 0.56 | 0.21 (95% CI 0.14β0.30) | 0.27 |
Age (years) | | | | | | |
ββ€56 | 0.72 (95% CI 0.60β0.84) | β | 0.29 (95% CI 0.17β0.41) | β | 0.21 (95% CI 0.12β0.31) | |
β>56 | 0.65 (95% CI 0.47β0.82) | 0.87 | 0.45 (95% CI 0.27β0.61) | 0.10 | 0.19 (95% CI 0.09β0.31) | 0.85 |
Hemoglobin level pre-RT (g/dL) | | | | | | |
ββ€12 | 0.64 (95% CI 0.46β0.83) | | 0.41 (95% CI 0.20β0.61) | | 0.17 (95% CI 0.07β0.31) | |
β>12 | 0.69 (95% CI 0.55β0.84) | 0.72 | 0.27 (95% CI 0.16β0.40) | 0.42 | 0.23 (95% CI 0.13β0.35) | 0.45 |
Tumor site | | | | | | |
βOropharynx | 0.72 (95% CI 0.58β0.86) | ββ | 0.44 (95% CI 0.27β0.59) | ββ | 0.14 (95% CI 0.07β0.23) | |
βHypopharynx | 0.65 (95% CI 0.51β0.80) | 0.35 | 0.28 (95% CI 0.16β0.41) | 0.46 | 0.27 (95% CI 0.15β0.40) | 0.30 |
T-Classification | | | | | | |
β1, 2 | 0.69 (95% CI 0.54β0.83) | β | 0.34 (95% CI 0.20β0.49) | β | 0.19 (95% CI 0.11β0.30) | |
β3, 4 | 0.70 (95% CI 0.56β0.83) | 0.80 | 0.37 (95% CI 0.23β0.52) | 0.60 | 0.20 (95% CI 0.11β0.32) | 0.94 |
N-Classification | | | | | | |
β0, 1 | 0.72 (95% CI 0.54β0.89) | β | 0.28 (95% CI 0.12β0.48) | β | 0.10 (95% CI 0.04β0.21) | |
β2, 3 | 0.68 (95% CI 0.55β0.80) | 0.24 | 0.40 (95% CI 0.27β0.53) | 0.06 | 0.26 (95% CI 0.16β0.36) | 0.03 |
R-Classification | | | | | | |
β0 | 0.68 (95% CI 0.56β0.80) | β | 0.37 (95% CI 0.23β0.50) | β | 0.21 (95% CI 0.11β0.31) | |
β1, 2 | 0.69 (95% CI 0.59β0.79) | 0.95 | 0.37 (95% CI 0.16β0.58) | 0.81 | 0.20 (95% CI 0.07β0.33) | 0.80 |
Total tumor volume (cm3) | | | | | | |
ββ€21.2 | 0.65 (95% CI 0.47β0.82) | | 0.23 (95% CI 0.09β0.37) | | 0.17 (95% CI 0.07β0.27) | |
β>21.2 | 0.61 (95% CI 0.45β0.76) | 0.13 | 0.44 (95% CI 0.27β0.60) | 0.04 | 0.26 (95% CI 0.14β0.39) | 0.25 |
RT interruptions >5 days | | | | | | |
βYes | 0.66 (95% CI 0.45β0.87) | β | 0.51 (95% CI 0.26β0.72) | β | 0.25 (95% CI 0.10β0.44) | |
βNo | 0.70 (95% CI 0.57β0.82) | 0.22 | 0.27 (95% CI 0.17β0.39) | 0.10 | 0.18 (95% CI 0.11β0.27) | 0.26 |
Interval surgery-RT >32 days | | | | | | |
Yes | 0.66 (95% CI 0.51β0.80) | 0.50 | 0.45 (95% CI 0.28β0.60) | 0.40 | 0.20 (95% CI 0.11β0.32) | 0.79 |
No | 0.70 (95% CI 0.54β0.85) | β | 0.27 (95% CI 0.15β0.40) | β | 0.20 (95% CI 0.11β0.32) | |
|