Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Table 5

Postoperative radiation therapy: multivariate analysis of overall survival, locoregional control, and metastasis-free survival.

Factor	Overall survival		Locoregional control		Metastasis-free survival
	RR	𝑃	RR	𝑃	RR	𝑃
Gender	0.34 (95% CI 0.04–2.74)	0.31	0.33 (95% CI 0.05–2.10)	0.24	0.63 (95% CI 0.05–8.47)	0.73
Age	1.11 (95% CI 0.49–2.54)	0.80	2.23 (95% CI 0.93–5.38)	0.07	1.05 (95% CI 0.36–3.04)	0.93
Hemoglobin level pre-RT	0.88 (95% CI 0.40–1.92)	0.75	0.79 (95% CI 0.32–1.93)	0.60	1.42 (95% CI 0.55–3.68)	0.47
Tumor site	0.98 (95% CI 0.42–2.26)	0.95	1.25 (95% CI 0.46–3.42)	0.66	0.65 (95% CI 0.25–1.72)	0.39
T-Classification	1.24 (95% CI 0.53–2.88)	0.62	1.85 (95% CI 0.77–4.42)	0.17	1.24 (95% CI 0.47–3.26)	0.66
N-Classification	1.17 (95% CI 0.45–3.09)	0.75	1.81 (95% CI 0.61–5.35)	0.28	2.25 (95% CI 0.72–7.01)	0.16
R-Classification	1.17 (95% CI 0.50–2.73)	0.72	0.79 (95% CI 0.34–1.87)	0.60	1.04 (95% CI 0.41–2.64)	0.94
Total tumor volume	1.77 (95% CI 0.76–4.14)	0.19	3.19 (95% CI 1.00–10.2)	0.05	1.03 (95% CI 0.37–2.85)	0.95
RT interruptions >5 days	1.42 (95% CI 0.57–3.50)	0.45	1.17 (95% CI 0.50–2.70)	0.72	1.15 (95% CI 0.31–4.31)	0.84
Interval surgery-RT >32 days	1.45 (95% CI 0.67–3.13)	0.35	1.92 (95% CI 0.81–4.54)	0.14	0.96 (95% CI 0.38–2.41)	0.93

RT: radiation therapy; RR: relative risk; 𝑃: 𝑃 value.