Research Article

Bevacizumab and Breast Cancer: A Meta-Analysis of First-Line Phase III Studies and a Critical Reappraisal of Available Evidence

Table 2

Ongoing a phase III clinical trials evaluating the addition of bevacizumab for the treatment of advanced breast cancer.

IdentifierSetting 𝑛 Study Design

NCT00600340Advanced560Bevacizumab + paclitaxel versus bevacizumab + capecitabine
NCT01303679Advanced198Bevacizumab + exemestane versus bevacizumab + paclitaxel
NCT01131195Advanced142Bevacizumab + paclitaxel versus metronomic ctx + capecitabine
NCT01250379Advanced488Chemotherapy + bevacizumab. versus chemotherapy*
NCT00929240AdvancedBevacizumab + capecitabine. versus bevacizumab**
NCT00785291Advanced900Bevacizumab + paclitaxel versus paclitaxel
Bevacizumab + nab-paclitaxel versus nab-paclitaxel
Bevacizumab + ixabepilone versus ixabepilone
NCT01200212Advanced432Bevacizumab + taxane + capecitabine versus taxane + capecitabine
NCT00545077Advanced378Letrozole or fulvestrant versus letrozole or fulvestrant + bevacizumab
NCT00601900Advanced502Tamoxifen or letrozole versus tamoxifen or letrozole + bevacizumab
NCT00391092Advanced407Bevacizumab + trastuzumab + docetaxel versus trastuzumab + docetaxel
NCT00520975Advanced489Bevacizumab + trastuzumab + carboplatin + paclitaxel versus trastuzumab + carboplatin + paclitaxel

Identifiers are from clinicaltrials.gov website. *Patients previously treated with bevacizumab. **Patients treated with bevacizumab and docetaxel and no evidence of progressive disease.
Abbreviations: 𝑛 : estimated number of patients.