Early Response to Dexamethasone as Prognostic Factor: Result from Indonesian Childhood WK-ALL Protocol in Yogyakarta

Table 2

Treatment outcome by groups of early response to treatment measured at day 8.

	Good responder (𝑁=133)		Poor responder (𝑛=32)		Total (𝑁=165)		OR	95% CI	𝑃 value
	𝑛	(%)	𝑛	(%)	𝑛	(%)
Induction treatment
Complete remission	102	76.7	15	46.9	117	70.9
Induction failures	31	23.3	17	53.1	48	29.1	3.73^a	1.67–8.32	0.001^1
Abandonment	14	10.5	6	18.8	20	12.1	2.91^a	0.97–8.75	0.09^2
Death	11	8.3	6	18.8	17	10.3	3.71^a	1.19–11.51	0.03^2
Resistant disease	6	4.5	5	15.6	11	6.7	5.67^a	1.54–20.89	0.01^2
Adverse event after CR
Continuous CR	33	32.4	3	20.0	36	30.8
Relapse	38	37.3	7	46.7	45	38.5	2.02^b	0.48–8.47	0.50^2
Death	16	15.7	3	20.0	19	16.2	2.06^b	0.37–11.38	0.40^2
Abandonment	15	14.7	2	13.3	17	14.5	1.47^b	0.22–9.71	0.65^2
Site of relapse	38		7
Isolated hematological	28	73.7	5	71.4	33	73.4
Isolated CNS	7	18.5	1	14.3	8	17.8
Other	3	7.8	1	14.3	4	9.8

OR: odds ratio for poor responders relative to good responders; CI: confidence interval; CR: complete remission. ^aORs for any induction failure and specific induction failures (CR during induction is taken as the reference outcome category). ^bORs for first event after CR (continuous CR is taken as the reference outcome category). ¹Chi-square test. ²Fisher exact test.