Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
Figure 2
Breast progressive array staining. (a) No TK1 staining was found in normal lobule breast tissue. However, TK1 staining was found in proliferating duct epithelial cells of precancerous tissue including, (b) breast adenosis, (c) breast adenosis with mild atypical hyperplasia of duct epithelium, and (d) moderate atypical hyperplasia of duct epithelium. Positive TK1 staining in the cytoplasm of tumor cells was also found in cancerous tissue such as, (e) intraductal carcinoma, (f) infiltrating duct carcinoma, and (g) medullary carcinoma tissues.
