WAVE2 Protein Complex Coupled to Membrane and Microtubules
Figure 3
Directional membrane targeting and anchoring of WAVE2 to PIP3 by IRSp53, leading to the directional formation of lamellipodia toward GF. (a) Promotion of microtubule growth through recruitment of the stathmin-EB1 complex to the microtubule ends induces membrane targeting of the WAVE2 complex along microtubules. The WAVE2 complex targets the cell cortex and is anchored by IRSp53. IRSp53 links WAVE2 to PIP3 produced by PI3K near GF-R locally activated in the membrane region facing GF. (b) Colocalization of WAVE2, IRSp53, and PIP3 results in the directional formation of lamellipodia towards high concentrations of GF. IRSp53: insulin receptor substrate p53; PIP3: phosphoinositide 3,4,5-triphosphate.
