DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression
Figure 4
Correlation of the expression levels of pChk2 and Rsf-1 (HBXAP). (a) Scatter plots showing the distribution of pChk2 (percentage) and Rsf-1 (HBXAP) (immunostaining intensity) in 75 high-grade serous carcinomas. The correlation between the percentage of pChk2 positive cells and Rsf-1 immunostaining intensity was significant (). Horizontal bars: means. (b) Scatter plots showing the distribution of pChk2 intensity scores and Rsf-1 (HBXAP) intensity scores in the same set of high-grade serous carcinomas. The correlation between immunostaining intensity of pChk2 and Rsf-1 was significant (). Horizontal bars: means. (c) Four representative cases of high-grade serous carcinomas showing different staining patterns of pChk2 and Rsf-1. The intensity scores are shown in the left upper corner of each panel.
