Oral Cavity and Pharynx Cancer Incidence Trends by Subsite in the United States: Changing Gender Patterns

Table 1

Squamous cell carcinoma of the oral cavity and pharynx incidence by time period, race/ethnicity, sex, and subsite.

Year of diagnosis

SEER areas

Race/ethnicity

Sex

Total

HPV-related

HPV-unrelated

Oral tongue

Cases

rate/ratio

(95% CI)

Cases

rate/ratio

(95% CI)

Cases

rate/ratio

(95% CI)

Cases

rate/ratio

(95% CI)

1975–1991

9

All whites

Male; Female

15,979; 8,343

12.3; 5.2

(12.1, 12.5); (5.1, 5.3)

4,682; 2,227

3.6; 1.4

(3.5, 3.7); (1.3, 1.4)

8,876; 4,597

6.9; 2.8

(6.7, 7.0); (2.8, 2.9)

2,421; 1,519

1.9; 0.9

(1.8, 1.9); (0.9, 1.0)

1975–1991

9

Blacks

Male; Female

2,594; 851

22.6; 5.9

(21.7, 23.5); (5.5, 6.4)

901; 300

7.8; 2.1

(7.3, 8.4); (1.9, 2.3)

1,442; 452

12.6; 3.2

(12.0, 13.3); (2.9, 3.5)

251; 99

2.2; 0.7

(1.9, 2.5); (0.6, 0.9)

1992–2008

9

All whites

Male; Female

18,539; 8,533

11.2; 4.4

(11.1, 11.4); (4.3, 4.4)

8,293; 2,352

4.9; 1.2

(4.8, 5.0); (1.2, 1.3)

7,155; 4,009

4.4; 2.0

(4.3, 4.5); (1.9, 2.1)

3,091; 2,172

1.9; 1.1

(1.8, 2.0); (1.1, 1.2)

1992–2008

9

Blacks

Male; Female

2,711; 934

15.5; 4.2

(14.9, 16.2); (3.9, 4.5)

1,222; 349

6.8; 1.5

(6.4, 7.2); (1.4, 1.7)

1,245; 469

7.3; 2.2

(6.9, 7.7); (2.0, 2.4)

244; 116

1.4; 0.5

(1.2, 1.6); (0.4, 0.6)

1992–2008

13

Whites (non-Hispanic)

Male; Female

22,657; 10,586

11.6; 4.5

(11.5, 11.8); (4.5, 4.6)

10,336; 2,955

5.2; 1.3

(5.1, 5.3); (1.3, 1.4)

8,553; 4,936

4.5; 2.1

(4.4, 4.6); (2.0, 2.1)

3,768; 2,695

2.0; 1.2

(1.9, 2.0); (1.1, 1.2)

1992–2008

13

Blacks

Male; Female

3,690; 1,311

15.1; 4.2

(14.6, 15.6); (4.0, 4.4)

1,649; 486

6.6; 1.5

(6.3, 7.0); (1.4, 1.7)

1,663; 631

6.9; 2.1

(6.6, 7.3); (1.9, 2.2)

378; 194

1.6; 0.6

(1.4, 1.7); (0.5, 0.7)

1992–2008

13

Hispanics (white)

Male; Female

1,895; 791

6.8; 2.4

(6.5, 7.1); (2.3, 2.6)

779; 217

2.6; 0.6

(2.4, 2.8); (0.6, 0.7)

803; 303

3.0; 1.0

(2.8, 3.3); (0.9, 1.1)

313; 271

1.1; 0.8

(1.0, 1.3); (0.7, 0.9)

1992–2008

13

Asian/PIs

Male; Female

1,655; 847

5.9; 2.5

(5.6, 6.2); (2.3, 2.6)

528; 153

1.8; 0.4

(1.7, 2.0); (0.4, 0.5)

683; 310

2.5; 0.9

(2.3, 2.7); (0.8, 1.0)

444; 384

1.5; 1.1

(1.4, 1.7); (1.0, 1.2)

1992–2008

13

AI/ANs

Male; Female

171; 76

5.9; 2.3

(5.0, 6.9); (1.8, 2.9)

72; 18

2.2; 0.5

(1.7, 2.8); (0.3, 0.8)

81; 35

3.1; 1.1

(2.4, 4.0); (0.8, 1.5)

18; 23

0.6; 0.7

(0.3, 0.9); (0.4, 1.0)

Male/female IRRs:

1975–1991

9

All whites

2.38

(2.32, 2.44)

2.57

(2.45, 2.71)

2.42

(2.34, 2.51)

1.96

(1.84, 2.09)

1975–1991

9

Blacks

3.80

(3.52, 4.11)

3.73

(3.27, 4.25)

4.00

(3.60, 4.45)

3.11

(2.46, 3.93)

1992–2008

9

All whites

2.58

(2.68, 2.76)

3.99

(4.68, 5.19)

2.22

(1.73, 1.93)

1.69

(1.60, 1.85)

1992–2008

9

Blacks

3.70

(3.43, 3.99)

4.47

(3.97, 5.03)

3.37

(3.03, 3.75)

2.77

(2.22, 3.46)

1992–2008

13

Whites (non-Hispanic)

2.56

(2.50, 2.62)

3.98

(3.82, 4.14)

2.16

(2.09, 2.24)

1.67

(1.59, 1.75)

1992–2008

13

Blacks

3.61

(3.39, 3.84)

4.32

(3.91, 4.78)

3.37

(3.07, 3.69)

2.60

(2.19, 3.09)

1992–2008

13

Hispanics (white)

2.77

(2.55, 3.01)

4.11

(3.54, 4.78)

2.99

(2.62, 3.41)

1.43

(1.21, 1.68)

1992–2008

13

Asian/PIs

2.39

(2.20, 2.60)

4.21

(3.52, 5.04)

2.68

(2.35, 3.07)

1.41

(1.23, 1.62)

1992–2008

13

AI/ANs

2.59

(1.97, 3.39)

4.14

(2.47, 6.94)

2.85

(1.92, 4.24)

0.88

(0.47, 1.63)

Oral cavity and pharynx excludes lip, salivary glands, and nasopharynx.
HPV-related includes base of tongue, lingual tonsil, tonsil, oropharynx, and Waldeyer ring.
Oral tongue includes dorsal and ventral surfaces, border, anterior 2/3, overlapping lesions, and tongue not otherwise specified.
Rates per 100,000 person-years, age-adjusted using the US 2000 population standard; 95% CI = 95% confidence interval.
IRRs: incidence rate ratios, based on unrounded rates.
Asian/PIs: Asian/Pacific Islanders.
AI/ANs: American Indian/Alaska Natives.