Clinical Study
Selenium in the Prevention of Anthracycline-Induced Cardiac Toxicity in Children with Cancer
Table 3
Se-supplemented patients with low serum Se levels, high Pro-BNP levels, and/or cardiac failure.
|
Pt.
|
Total anthracy
mg/m2 |
Pro-BNP
pg/mL |
Se
mcg/L |
ECHO |
Cardiac failure |
Digoxin
Enalapril
Furosem |
Se
Suppl. | End results | | Echo | (i) Pro-BNP
(pg/mL) | (ii) Pro-BNP
(pg/mL) | (i) Se
(mcg/L) | (ii) Se
(mcg/L) |
| | ES | 550 | 754 | 70 | Systolic failure | + | + | 100 mcg | Normal | 536 | 123.5 | 108 | 86 | | NBL | 180 | 175 | 52 | Systolic failure | + | + | 100 mcg | Normal | 85 | 95 | 103 | 106 | | ACC | 400 | 10 | 71 | Diastolic failure | − | − | 100 mcg | Normal | 10 | 10 | 65 | 75 | | HL | 300 | 843 | 55 | Diastolic failure | − | − | 100 mcg | Normal | 298 | 118 | 72 | 81 | | NHL | 240 | 172 | 49.2 | Normal | − | − | 100 mcg | Normal | 12.6 | NA | 109 | NA | | HL | 400 | 197.5 | 20 | Normal | − | − | 100 mcg | Normal | 80 | NA | 208 | NA | | BL | 150 | 170.4 | 57 | Normal | − | − | 100 mcg | Normal | 2 | NA | 75 | NA | | NHL | 120 | 277 | 83 | Systolic failure | + | + | 100 mcg | Normal | NA | NA | NA | NA | | RMS | 0 | 127 | 62 | Intracardiac thrombus | − | − | — | Normal | 67 | NA | NA | NA | | AML | 400 | 8022 | 65 | Normal | − | − | — | Died | NA | NA | NA | NA | | TALL | 320 | 1536 | 129 | Pericardial effusion, tamponade | − | − | — | Died | NA | NA | NA | NA |
|
|
Pt: patient; NA: not available, ES: Ewing’s sarcoma, NBL: neuroblastoma, ACC: adrenocortical carcinoma, HL: Hodgkin lymphoma, NHL: non-Hodgkin lymphoma, BL: Burkitt lymphoma, RMS: rhabdomyosarcoma, AML: acute myeloid leukemia; T ALL: T acute lymphoblastic leukemia.
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