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Journal of Oncology
Volume 2012, Article ID 680796, 15 pages
http://dx.doi.org/10.1155/2012/680796
Review Article

Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma

Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road First Section, Taipei 100, Taiwan

Received 6 September 2011; Accepted 22 November 2011

Academic Editor: Matthew E. Hyndman

Copyright © 2012 Sai-Wen Tang and Jung-Yaw Lin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Clear cell renal cell carcinoma (ccRCC), the most common subtype of RCC, is characterized by high metastasis potential and strong resistance to traditional therapies, resulting in a poor five-year survival rate of patients. Several therapies targeted to VEGF pathway for advanced RCC have been developed, however, it still needs to discover new therapeutic targets for treating RCC. Genome-wide gene expression analyses have been broadly used to identify unknown molecular mechanisms of cancer progression. Recently, we applied the oligo-capping method to construct the full-length cDNA libraries of ccRCC and adjacent normal kidney, and analyzed the gene expression profiles by high-throughput sequencing. This paper presents a review for recent findings on therapeutic potential of MYC pathway and nicotinamide N-methyltransferase for the treatment of RCC.