Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma

Table 2

Plasma VEGF and sVEGFR-1 levels and VR secretion profile.

Variable	Normal (𝑛=32)	HNSCC (𝑛=82)	𝑃
VEGF, pg/mL
Mean (SD)	41.7 (50.1)	71.1 (133.7)
Median (IQR)	22.8 (14.5–38.1)	29.4 (19.3–73.9)	0.03
sVEGFR-1, pg/mL
Mean (SD)	35.3 (30.1)	45.1 (27.7)
Median (IQR)	27.9 (19.5–34)	37.2 (29.8–54.3)	0.0001
VR secretion profile			0.03
VHRL, 𝑛 (%)	9 (28.1)	11 (13.6)
VHRH, 𝑛 (%)	8 (25)	45 (54.9)
VLRH, 𝑛 (%)	10 (31.3)	17 (20.7)
VLRL, 𝑛 (%)	5 (15.6)	9 (11)