Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma

Table 4

VR secretion profile and VEGF and sVEGFR-1 concentrations in correlation with stepwise increase in combined tumor grade and stage.

Tumor grade and stage	VR secretion profile, 𝑛 (%)				VEGF, pg/mL		sVEGFR-1, pg/mL
	VHRL	VHRH	VLRH	VLRL	Median (range)	𝑃^∗	Median (range)	𝑃^∗
Normal control	9	8	10	5	22.9	—	27.86	—
(𝑛=32)	(28.1)	(25)	(31.3)	(15.6)	(7.1–228.7)		(10.4–147.4)
G1,2T1,2 N−	2	5	6	3	20.6	0.46	32.74	0.04
(𝑛=16)	(12.5)	(31.3)	(37.5)	(18.8)	(10.2–124.6)		(18.1–194)
G1,2T3,4 N−	1	6	5	2	21.6	0.30	43.7	0.004
(𝑛=14)	(7.1)	(42.9)	(35.7)	(14.3)	(1.3–168)		(17.3–171)
G1,2T1-4 N+	4	9	3	4	25.6	0.20	33.32	0.03
(𝑛=20)	(20)	(45)	(15)	(20)	(13.4–1121.9)		(21.2–78)
G3,4T2-4 N−	3	6	1	0	91.5	0.002	35.79	0.04
(𝑛=10)	(30)	(60)	(10)	(0)	(21.3–271.6)		(15.5–54.1)
G3,4T3-4 N+	1	19	2	0	65.4	0.0008	58.84	<.0001
(𝑛=22)	(4.5)	(86.4)	(9.1)	(0)	(17.5–258.5)		(28.8–92.4)

*Comparison between patients and normal controls.