Early Detection Biomarkers for Ovarian Cancer

Table 1

Specificity and sensitivity of early detection biomarkers for ovarian cancer from various studies.

Biomarker	Early detection biomarkers: ovarian cancer (sensitivity and specificity)
	Source	n (Total)	Specificity	Sensitivity	Levels	Benign (n)	Other malignancies (n)	Ovarian (n)	Reference
HE4	Serum	233	95%	73%	High	166	NA	67	[39]
HE4 + CA125	Serum	472	74.20%	100%	High	383	89	10%	[36]
			76%	92.30%
Prostasin + CA125	Serum	137	94%	92%	High	100	37	37	[91]
Osteopontin	Plasma	251	NA	NA	High	107	47	51	[138]
KLK6 (hK6)	Serum	384	95%	21%–26%	High	141	NA	146	[55]
KLK6 + CA125	Serum	384	90%	42%	High	141	NA	146	[55]
B7-H4	Serum	2256	97%	45%	High	1023	997	236	[140]
B7-H4 + CA125	Serum	2256	97%	65%	High	1023	410	236	[141]

n: number of patients.