Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells
Apoptotic morphological changes such as abnormal nuclear morphology, reduction in cell number with apoptotic body formation, and cell shrinkage induced by combination treatment with curcumin and garcinol in different ratios for 48 hours were observed using DAPI stain in both PaCa cell lines: BxPC-3 (left panel) and Panc-1 (right panel). (1 : 4 ratio is 2.5 μM : 10 μM concentration and 1 : 10 ratio is 2 μM : 20 μM respective concentrations).
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