MicroRNAs in Human Malignant Gliomas

Table 1

Dysregulated miRNAs in glioblastoma.

Authors	Year	Reference	Methods	Number of miRNA	Comparison	Upregulation	Downregulation
Guan et al.						miR-15b	miR-105
						miR-21	miR-128-2
						miR-135(b)	miR-184
						miR-196a	miR-302b
	2010	[19]	TaqMan array	365	GBM versus AA	miR-196b	miR-302d
						miR-363	miR-367
							miR-383
							miR-504
							miR-517c
							miR-601
Ciafrè et al.	2005	[13]	Microarray	245	GBM versus NB	miR-9	miR-128-1
						miR-10b	miR-181a
						miR-21	miR-181b
						miR-25	miR-181c
						miR-123
						miR-125b-1
						miR-125b-2
						miR-130a
						miR-221
Chan et al.	2005	[12]	Microarray	180	GBM versus NB	miR-21	miR-188
						miR-135(b)	miR-198
						miR-138	miR-202
						miR-291-5^′
						miR-347
Godlewski et al.	2008	[15]	Microarray	161	GBM versus ANB	miR-10b	miR-124a
						miR-21	miR-128-1
						miR-26	miR-128-2
						miR-383	miR-137
						miR-451	miR-139
						miR-486	miR-190
						miR-516-35p	miR-218
						miR-519d	miR-299
							miR-323
							miR-483
							miR-511-1
Sasayama et al.	2009	[16]	Microarray	127 or 188	GBM versus ANB	miR-10b	miR-134
						miR-21	miR-302c
						miR-92b	miR-329
						miR-106b	miR-369-3p
						miR-183	miR-379
Malzkorn et al.	2010	[20]	TaqMan	157	GBM versus DA	miR-9	miR-184
						miR-15a	miR-328
						miR-16
						miR-17
						miR-19a
						miR-20a
						miR-21
						miR-25
						miR-28
						miR-130b
						miR-140
						miR-210
Rao et al.	2010	[22]	LNA array	756	GBM versus AA	miR-16	miR-128-1
						miR-21	miR-128-2
						miR-22	miR-219-2-3p
						miR-24
						miR-34a
						miR-126
						miR-142-5p
						miR-143
						miR-146b-5p
						miR-155
						miR-193a-3p
						miR-199a/b-3p
						miR-335
						miR-376c
						miR-381
						miR-451
						miR-509-3-5p
						miR-513a-5p
						miR-552
						miR-886-3p/5p

GBM: glioblastoma, AA: anaplastic astrocytoma, NB: normal brain, ANB: adjacent normal brain, and DA: diffuse astrocytoma. Bold: common dysregulated miRNA (more than 3 reports).