Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases

Table 5

Endothelial cell proliferation (ECP)/tumour cell proliferation (TCP).

Growth pattern	Number of CRLM	ECP mean: 95% CI interval	TCP mean: 95% CI interval	ECP/TCP mean: 95% CI interval
Desmoplastic	16	0.020: 95% 0.013–0.040	0.50: 95% 0.28–0.89	0.048: 95% 0.029–0.079
Pushing	21	0.028: 95% 0.020–0.040	0.16: 95% 0.10–0.26	0.160: 95% 0.093–0.270
Replacement	13	0.019: 95% 0.011–0.030	0.27: 95% 0.20–0.38	0.068: 95% 0.039–0.120
Mixed	12	0.020: 95% 0.012–0.036	0.16: 95% 0.11–0.29	0.113: 95% 0.066–0.196

ECP: endothelial cell proliferation, TCP: tumour cell proliferation and ECP/TCP which is the value representing angiogenesis dependent growth.
ECP/TCP, pushing versus desmoplastic, 𝑃=0.0007.
ECP/TCP, pushing versus replacement, 𝑃=0.021.