Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

Figure 3

Molecular mechanisms and targets for Akt-mediated genomic instability. Akt can inhibit DNA repair, recombination, and checkpoint signalling by phosphorylating key regulatory proteins such as Chk1, TopBP1, Brca1, and RPS3 at specific sites. Please see text for additional explanation.