Altered and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer
Figure 1
p16INK4 immunohistochemical staining in lung cancer samples. The patterns in tumor cells range from strong (3+) in an adenocarcinoma with acinar differentiation, moderate (2+) in a mixed adenocarcinoma, and weak (1+) in a mixed adenocarcinoma from (a) to (c), respectively. No (0) expression was seen in tumor cells from a large cell neuroendocrine carcinoma (d) and an adenocarcinoma with acinar differentiation (e-f). There is no expression in normal lung tissue (f) or stromal including normal lymphocytes of the the tumor samples (a–e).
