Altered and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer
Figure 2
Gene copy variances of CDKN2A evaluated by FISH. (a) Representative example of tumor cells with increased CDKN2A gene copy numbers: the multiple red CDKN2A signals with fewer green CEP9 signals indicate the amplification (ratio >2.1). (b). Representative example of tumor cells with homozygous loss: the two or multiple green CEP9 signals but absent of red CDKN2A signals in tumor cells indicate specific loss of this gene rather than total loss of chromosome 9 (ratio = 0). Note a possible stromal cell with a normal signal pattern (2 red and 2 green) at the lower right corner of (b).
