Research Article
Disseminated Tumor Cells in Bone Marrow of Gastric Cancer Patients: Correlation with Tumor Hypoxia and Clinical Relevance
Table 2
Prevalence of disseminated tumor cells in bone marrow by clinical variables.
| | Variables | All patients (, 100%) | Patients with DTC (, 57.3%) | Patients without DTC (, 42.7%) |
| | Gender | | | | | Male | 62 | 27 (43.5) | 35 (56.5) | | Female | 27 | 17 (63.0) | 10 (37.0) | | Patients age groups (, %) | | | | | ≤65 | 56 | 35 (62.5) | 21 (37.5) | | >65 | 33 | 16 (48.5) | 17 (51.5) | | Age (years; median, range) | 62 (34–84) | | | | Tumor location | | | | | Upper third | 9 | 6 (66.7) | 3 (33.3) | | Middle third | 29 | 13 (44.8) | 16 (55.2) | | Lower third | 47 | 22 (46.8) | 25 (63.2) | | Total | 4 | 3 (75.0) | 1 (25.0) | | UICC Stage | | | | | I | 22 | 11 (50.0) | 11 (50.0) | | II | 16 | 6 (37.5) | 10 (62.5) | | III | 23 | 10 (43.5) | 13 (56.5) | | IV | 28 | 17 (60.7) | 11 (39.3) | | Histological type | | | | | Adenocarcinoma | 61 | 26 (42.6) | 35 (57.4) | | Mucinous adenocarcinoma | 12 | 8 (66.7) | 4 (33.3) | | Signet-ring carcinoma | 13 | 8 (61.5) | 5 (38.5) | | Undifferentiated carcinoma | 3 | 2 (66.7) | 1 (33.3) | | Grade (G) | | | | | 1 | 6 | 3 (50.0) | 3 (50.0) | | 2 | 15 | 4 (26.7) | 11 (73.3) | | 3 | 60 | 33 (55.0) | 27 (45.0) | | 4 | 8 | 4 (50.0) | 4 (50.0) | | T-classification | | | | | T1 | 10 | 3 (30.0) | 7 (70.0) | | T2 | 18 | 13 (72.2) | 5 (27.8) | | T3 | 33 | 15 (45.6) | 18 (54.5) | | T4 | 28 | 13 (46.4) | 15 (53.6) | | Nodal involvement | | | | | N0 | 43 | 18 (41.9) | 25 (58.1) | | N1 | 17 | 9 (52.9) | 8 (47.1) | | N2 | 29 | 17 (58.6) | 12 (41.4) | | Distant metastasis | | | | | M0 | 70 | 36 (51.4) | 34 (48.6) | | M1 | 19 | 15 (78.9) | 4 (21.1) | | Systemic therapy | | | | | Operation only | 47 | 27 (57.4) | 20 (42.6) | | Adjuvant chemotherapy | 42 | 24 (57.1) | 18 (42.9) |
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