Epithelial Plasticity in Cancer: Unmasking a MicroRNA Network for TGF-β-, Notch-, and Wnt-Mediated EMT

Table 1

List of experimentally validated miRNA—gene interactions for TGF-β signalling pathway. Interactions with Notch and Wnt signalling are also indicated (genes among those in TGF-β pathway).

miRNA	Gene (TGF- pathway)	Notch signalling	Wnt signalling
hsa-miR-335-5p	INHBB, SMAD3, ID4, ACVR1, ACVR2B, E2F5, MYC, BMP2, SP1, GDF5, AMHR2, TGFB2, THBS3, LTBP1, TGFBR2, INHBE	—	SMAD3, MYC
hsa-miR-34a-5p	E2F5, MYC	—	MYC
hsa-miR-1	E2F5, BMP7, THBS1	—	—
hsa-miR-124-3p	ID2, ROCK2, ID4, BMP6, RHOA, E2F5, SMAD5, ID1, SP1, BMPR1A, ID3, E2F4, PPP2R1B	—	ROCK2,  RHOA,  PPP2R1B
hsa-miR-26b-5p	SMAD6, BMP8B, RPS6KB2, ID1, BMP2, EP300, IFNG, SMAD7, BMPR2	EP300	EP300
hsa-miR-155-5p	SMAD2, THBS1, SMAD3, RHOA, SMAD5, SMAD1	—	SMAD2,  SMAD3,  RHOA
hsa-miR-375	CDKN2B, RHOA, TGFB2	—	RHOA
hsa-miR-21-5p	TGFBR1, THBS1, ZFVYE16, MYC, TGFB2, TGFBR2, BMPR2	—	MYC
hsa-miR-98	TGFBR1, THBS1, CDKN2B, RPS6KB2, MYC, SMAD7, INHBE, RPS6KB1	—	MYC
hsa-miR-122-5p	NODAL, SMURF2, RHOA	—	RHOA
hsa-miR-200c-3p	EP300	EP300	EP300
hsa-miR-9-5p	ID4, EP300	EP300	EP300
hsa-miR-324-3p	CREBBP	CREBBP	CREBBP
hsa-miR-24-3p	MYC	—	MYC
hsa-miR-194-5p	EP300	EP300	EP300
hsa-miR-92a-3p	THBS1, SMAD4, TGFBR2, BMPR2	—	SMAD4
hsa-miR-16-5p	SMURF2, PPP2R1A, SMAD5, ACVR2A, SP1, SMAD7, SMAD1, RPS6KB1	—	PPP2R1A
hsa-miR-93-5p	TGFBR2, BMPR2	—	—
hsa-miR-19a-3p	SMAD4, TGFBR2, BMPR2	—	SMAD4
hsa-miR-103a-3p	ACVR2B, SMAD7, RPS6KB1	—	—
hsa-miR-132-3p	THBS1	—	—
hsa-miR-30a-5p	THBS1, MAPK1	—	—
hsa-miR-200b-3p	EP300	EP300	EP300
hsa-miR-19b-3p	ACVR1, SMAD4, TGFBR2, BMPR2	—	SMAD4
hsa-miR-145-5p	MYC	—	MYC
hsa-miR-31-5p	RHOA	—	RHOA
hsa-miR-429	EP300	EP300	EP300
hsa-miR-10a-5p	ACVR2A	—	—
hsa-miR-182-5p	EP300	EP300	EP300
Hsa-miR-374a-5p	EP300	EP300	EP300