Epithelial Plasticity in Cancer: Unmasking a MicroRNA Network for TGF-β-, Notch-, and Wnt-Mediated EMT

Table 2

List of experimentally validated miRNA—gene interactions for Wnt signalling pathway. Interactions with Notch and TGF- signalling are also indicated (genes among those in Wnt pathway).

miRNA	Gene (Wnt pathway)	Notch signalling	TGF- signalling
hsa-miR-335-5p	CTNNBIP1, LRP6, TBL1X, WNT10B, CCND2, DKK2, SMAD3, AXIN1, WNT3, FZD8, PPP2R5A, NFAT5, FZD10, MYC, VANGL2, PRKCG, DKK4, FZD1, PRICKLE2, SFRP1, WIF1, DAAM1, WNT7B, WNT9A, PPP3R2	—	SMAD3, MYC
hsa-miR-34a-5p	WNT1, CCND1, CTNNB1, AXIN2, MYC, PPP3R1, LEF1, MAP3K7, CCND3	—	MYC
hsa-miR-1	CSNK2A2, CAMK2G, CTBP1, CTBP2, PPP2R5A, PLCB3, CCND1, DKK1	CTBP1, CTBP2	—
hsa-miR-124-3p	VANGL1, PORCN, ROCK2, RHOA, WNT5B, CTNNB1, PPP2R1B, NFATC1, DVL2	DVL2	ROCK2, PPP2R1B, RHOA
hsa-miR-26b-5p	SFRP4, DVL3, FZD5, RUVBL1, VANGL1, GPC4, JUN, CCND1, VANGL2, PPP3R1, EP300, PLCB4, PLCB2	EP300,  DVL3	EP300
hsa-miR-155-5p	GSK3B, SMAD2, APC, VANGL1, WNT5A, SMAD3, CSNK1A1L, RHOA, CTNNB1, CSNK1A1, RAC1, PSEN1	PSEN1	SMAD2,  SMAD3,  RHOA,
hsa-miR-375	PRKCA, RHOA, FZD4, PRKX	—	RHOA
hsa-miR-21-5p	TCF4, APC, WNT1, WNT5A, NFAT5, CSNK1A1, MYC, PRICKLE2, DAAM1, TBL1XR1	—	MYC
hsa-miR-98	VANGL1, WNT10B, SENP2, FZD10, MYC	—	MYC
hsa-miR-122-5p	RHOA, RAC1, TBL1XR1	RHOA	RHOA
hsa-miR-200c-3p	TCF7L1, EP300	EP300	EP300
hsa-miR-9-5p	WNT8A, WNT6, EP300, NFATC3, PLCB4	EP300	EP300
hsa-miR-324-3p	WNT9B, CREBBP, DVL2	CREBBP,  DVL2	CREBBP
hsa-miR-24-3p	FZD5, CHD8, FZD4, NFAT5, NKD1, MYC, PPP3R1	—	MYC
hsa-miR-194-5p	EP300	EP300	EP300
hsa-miR-92a-3p	SMAD4	—	SMAD4
hsa-miR-16-5p	CAMK2G, WNT5A, CCND2, PPP2R5C, JUN, CCND1, AXIN2, PPP2R1A, WNT3A, CCND3	—	PPP2R1A
hsa-miR-93-5p	MAPK9, CCND1, PRKACB	—	—
hsa-miR-19a-3p	CCND1, SMAD4	—	SMAD4
hsa-miR-103a-3p	AXIN2, WNT3A, MAP3K7	—	—
hsa-miR-132-3p	WNT3A	—	—
hsa-miR-30a-5p	WNT5A, PPP2R5C, PPP3CA, JUN, CTNNB1, PPP3R1	—	—
hsa-miR-200b-3p	TCF7L1, EP300	EP300	EP300
hsa-miR-19b-3p	DAAM2, TCF4, CCND2, SMAD4, PRKACB	—	SMAD4
hsa-miR-145-5p	PPP3CA, MYC	—	MYC
hsa-miR-31-5p	RHOA, NFAT5	—	RHOA
hsa-miR-429	TCF7L1, EP300	EP300	EP300
hsa-miR-10a-5p	BTRC, MAPK8, MAP3K7	—	—
hsa-miR-182-5p	EP300	EP300	EP300
Hsa-miR-374a-5p	EP300	EP300	EP300