Clinical Study

Pulmonary Venous Obstruction in Cancer Patients

Table 1

Characteristics and important laboratory and imaging findings of 222 cancer patients with pulmonary vein obstruction syndrome (PVOS).

CharacteristicsNumber of patients (%)

Age (years)
 Median (range) 69 (27–93)
Sex
 Male/female139/83
Primary sites: number/total hospitalized number (%)
 All patients 222/1117 (20)
 Urinary tract80/395 (20)
 Lung31/115 (27)
 Colorectum15/67 (22)
 Breast 18/58 (31)
 Pancreas 8/46 (17)
 Stomach7/38 (18)
 Prostate7/29 (24)
 Others 56/369 (13)
Performance status: number/total number (%)
 0-155/222 (25)
 ≥2167/222 (75)
Associated with other thromboembolic complications: number/total number (%)
 Yes 146/222 (66)
 No 76/222 (34)
Associated with other paraneoplastic syndromes: number/total number (%)
 Yes 101/222 (45)
 No 121/222 (55)
Acute respiratory distress: number/total number
 Aggravated by chemotherapy 28/222 (13)
 Aggravated by medical/surgical procedure 21/222 (9)
 Showed diurnal rhythm 32/222 (14)
D-dimer (ng/mL): number/total number (%)
 ≦100025/222 (11)
 1001–300078/222 (35)
 3001–500051/222 (23)
 >500068/222 (31)
C-reactive protein (mg/L): number/total number
 ≦10 6/111 (5)
 >11 105/111 (95)
Chest plain film: number/total number
 Abnormal hilum shadow222/222 (100)
  By side
   Bilateral lung175/222 (79)
   Unilateral lung 47/222 (21)
  By location
   Upper lung + lower lung 186/222 (84)
   Upper lung only19/222 (9)
   Lower lung only17/222 (8)
  Pulmonary edema194/222 (87)
  Pleural effusion 192/222 (86)
CT scan: number/total number
 Pulmonary veins thrombosis/tumor 222/222 (100)
 Surrounding pulmonary veins by tumor/atelectasis/consolidation 140/222 (63)
 By side
  Bilateral lung204/222 (92)
  Unilateral lung18/222 (8)
 By location
  Both superior and inferior pulmonary vein203/222 (91)
  Superior pulmonary vein only 11/222 (5)
  Inferior pulmonary vein only8/222 (4)
 Pulmonary artery emboli 70/222 (32)
 Pleural effusion 155/222 (70)