Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2015, Article ID 316745, 8 pages
http://dx.doi.org/10.1155/2015/316745
Research Article

Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma

Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan

Received 10 October 2014; Accepted 30 November 2014

Academic Editor: James L. Mulshine

Copyright © 2015 Jun Osugi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Keith and M. C. Simon, “Hypoxia-inducible factors, stem cells, and cancer,” Cell, vol. 129, no. 3, pp. 465–472, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. G. L. Semenza and G. L. Wang, “A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation,” Molecular and Cellular Biology, vol. 12, no. 12, pp. 5447–5454, 1992. View at Google Scholar · View at Scopus
  3. G. L. Semenza, “Targeting HIF-1 for cancer therapy,” Nature Reviews Cancer, vol. 3, no. 10, pp. 721–732, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Weidemann and R. S. Johnson, “Biology of HIF-1α,” Cell Death and Differentiation, vol. 15, no. 4, pp. 621–627, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Giatromanolaki, M. I. Koukourakis, E. Sivridis et al., “Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival,” British Journal of Cancer, vol. 85, no. 6, pp. 881–890, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. D. E. B. Swinson, J. L. Jones, G. Cox, D. Richardson, A. L. Harris, and K. J. O'Byrne, “Hypoxia-inducible factor-1α in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways,” International Journal of Cancer, vol. 111, no. 1, pp. 43–50, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. S. K. Lau, P. C. Boutros, M. Pintilie et al., “Three-gene prognostic classifier for early-stage non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 25, no. 35, pp. 5562–5569, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Yohena, I. Yoshino, T. Takenaka et al., “Upregulation of hypoxia-inducible factor-1αmRNA and its clinical significance in non-small cell lung cancer,” Journal of Thoracic Oncology, vol. 4, no. 3, pp. 284–290, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. L. M. Greenberger, I. D. Horak, D. Filpula et al., “A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth,” Molecular Cancer Therapeutics, vol. 7, no. 11, pp. 3598–3608, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. J. J. Jacoby, B. Erez, M. V. Korshunova et al., “Treatment with hif-1α antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice,” Journal of Thoracic Oncology, vol. 5, no. 7, pp. 940–949, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, and T. Tuschl, “Identification of novel genes coding for small expressed RNAs,” Science, vol. 294, no. 5543, pp. 853–858, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. N. C. Lau, L. P. Lim, E. G. Weinstein, and D. P. Bartel, “An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans,” Science, vol. 294, no. 5543, pp. 858–862, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. R. C. Lee and V. Ambros, “An extensive class of small RNAs in Caenorhabditis elegans,” Science, vol. 294, no. 5543, pp. 862–864, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Kulshreshtha, M. Ferracin, S. E. Wojcik et al., “A microRNA signature of hypoxia,” Molecular and Cellular Biology, vol. 27, no. 5, pp. 1859–1867, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. W. C. S. Cho, A. S. C. Chow, and J. S. K. Au, “Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation,” European Journal of Cancer, vol. 45, no. 12, pp. 2197–2206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Miko, Z. Czimmerer, E. Cśanky et al., “Differentially expressed micrornas in small cell lung cancer,” Experimental Lung Research, vol. 35, no. 8, pp. 646–664, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Raponi, L. Dossey, T. Jatkoe et al., “MicroRNA classifiers for predicting prognosis of squamous cell lung cancer,” Cancer Research, vol. 69, no. 14, pp. 5776–5783, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Volinia, G. A. Calin, C.-G. Liu et al., “A microRNA expression signature of human solid tumors defines cancer gene targets,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 7, pp. 2257–2261, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Yanaihara, N. Caplen, E. Bowman et al., “Unique microRNA molecular profiles in lung cancer diagnosis and prognosis,” Cancer Cell, vol. 9, no. 3, pp. 189–198, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Camps, F. M. Buffa, S. Colella et al., “Hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer,” Clinical Cancer Research, vol. 14, no. 5, pp. 1340–1348, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. M. E. Crosby, R. Kulshreshtha, M. Ivan, and P. M. Glazer, “MicroRNA regulation of DNA repair gene expression in hypoxic stress,” Cancer Research, vol. 69, no. 3, pp. 1221–1229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Huang, L. Ding, K. L. Bennewith et al., “Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation,” Molecular Cell, vol. 35, no. 6, pp. 856–867, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Zhang, H. Sun, H. Dai et al., “MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT,” Cell Cycle, vol. 8, no. 17, pp. 2756–2768, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. A. M. Cheng, M. W. Byrom, J. Shelton, and L. P. Ford, “Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis,” Nucleic Acids Research, vol. 33, no. 4, pp. 1290–1297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Fasanaro, Y. D'Alessandra, V. Di Stefano et al., “MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3,” The Journal of Biological Chemistry, vol. 283, no. 23, pp. 15878–15883, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Giannakakis, R. Sandaltzopoulos, J. Greshock et al., “miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer,” Cancer Biology and Therapy, vol. 7, no. 2, pp. 255–264, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Y. Chan, Y.-Y. Zhang, C. Hemann, C. E. Mahoney, J. L. Zweier, and J. Loscalzo, “MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2,” Cell Metabolism, vol. 10, no. 4, pp. 273–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Chen, Y. Li, H. Zhang, P. Huang, and R. Luthra, “Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression,” Oncogene, vol. 29, no. 30, pp. 4362–4368, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. H. W. Kim, H. K. Haider, S. Jiang, and M. Ashraf, “Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2,” The Journal of Biological Chemistry, vol. 284, no. 48, pp. 33161–33168, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. H. E. Gee, C. Camps, F. M. Buffa et al., “hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer,” Cancer, vol. 116, no. 9, pp. 2148–2158, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Greither, L. F. Grochola, A. Udelnow, C. Lautenschläger, P. Würl, and H. Taubert, “Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival,” International Journal of Cancer, vol. 126, no. 1, pp. 73–80, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Li, X. Ma, B. Zhang, J. Huang, L. Liu, and Y. Wei, “Prognostic role of MicroRNA-210 in various carcinomas: a systematic review and meta-analysis,” Disease Markers, vol. 2014, Article ID 106197, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Wang, J. Zhao, M. Shi et al., “Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis,” PLoS ONE, vol. 9, no. 2, Article ID e89223, 2014. View at Publisher · View at Google Scholar
  35. N. Sawabata, E. Miyaoka, H. Asamura et al., “Japanese lung cancer registry study of 11,663 surgical cases in 2004: demographic and prognosis changes over decade,” Journal of Thoracic Oncology, vol. 6, no. 7, pp. 1229–1235, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Guan, Z. Yin, X. Li, W. Wu, and B. Zhou, “Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues,” Journal of Experimental and Clinical Cancer Research, vol. 31, no. 1, article 54, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Eilertsen, S. Andersen, S. Al-Saad et al., “Positive prognostic impact of miR-210 in non-small cell lung cancer,” Lung Cancer, vol. 83, no. 2, pp. 272–278, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. M.-P. Puisségur, N. M. Mazure, T. Bertero et al., “miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity,” Cell Death and Differentiation, vol. 18, no. 3, pp. 465–478, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. Z.-H. Li, H. Zhang, Z.-G. Yang, G.-Q. Wen, Y.-B. Cui, and G.-G. Shao, “Prognostic significance of serum microRNA-210 levels in nonsmall-cell lung cancer,” The Journal of International Medical Research, vol. 41, no. 5, pp. 1437–1444, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Qu, L. Du, Y. Yang et al., “Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer,” PLoS ONE, vol. 9, no. 3, Article ID e90952, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Qiu, S. Lin, D. Hu, Y. Feng, Y. Tan, and Y. Peng, “Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients,” Journal of Translational Medicine, vol. 11, no. 1, article 10, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. R. I. McCormick, C. Blick, J. Ragoussis et al., “miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis,” British Journal of Cancer, vol. 108, no. 5, pp. 1133–1142, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. X. Chen, Y. Ba, L. Ma et al., “Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases,” Cell Research, vol. 18, no. 10, pp. 997–1006, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Wang, J. Chen, P. Chang et al., “MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease,” Cancer Prevention Research, vol. 2, no. 9, pp. 807–813, 2009. View at Publisher · View at Google Scholar · View at Scopus