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Journal of Oncology
Volume 2015 (2015), Article ID 746917, 7 pages
Research Article

Adjuvant Iodine131 Lipiodol after Resection of Hepatocellular Carcinoma

1Department of Surgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
2Department of Nuclear Medicine, Repatriation General Hospital, Hospital Road, Concord, NSW 2137, Australia
3Department of Medical Oncology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia

Received 18 July 2015; Revised 29 October 2015; Accepted 1 November 2015

Academic Editor: Thomas R. Chauncey

Copyright © 2015 Ruelan V. Furtado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Survival after liver resection for HCC is compromised by a high rate of intrahepatic recurrence. Adjuvant treatment with a single, postoperative dose of intra-arterial I131 lipiodol has shown promise, as a means of prolonging disease-free survival (DFS). Methodology. DFS and overall survival (OS) after a single dose of postoperative I131 lipiodol were compared to liver resection alone, for treatment of hepatocellular carcinoma (HCC). Data were collected retrospectively for patients who had a curative resection for HCC between December 1993 and September 2011. Seventy-two patients were given I131 lipiodol after surgery and 70 patients had surgery alone. Results. The DFS at 1, 3, and 5 years was 72%, 43%, and 26% in the surgery group and 70%, 39%, and 29% in the adjuvant I131 lipiodol group . The 1-, 3-, and 5-year OS was 83%, 64%, and 52% in the surgery group and 96%, 72%, and 61% in the adjuvant I131 lipiodol group . Conclusion. This retrospective study has found no significant benefit to survival, after adjuvant treatment with I131 lipiodol.