Role of Rebiopsy in Relapsed Non-Small Cell Lung Cancer for Directing Oncology Treatments

Table 1

Techniques for obtaining tissue.

Method	Nature of sample	Size	Suitable for
Sputum	Cytology	50 mg	Limited immunohistology
Bronchoscopy brushing	Cytology	50 mg	Limited immunohistology
Fine needle biopsy	Cytology	100 mg	Immunohistology and PCR
Core needle biopsy	Histology	200–400 mg	Plus gene mutation testing, FISH, and DNA tests
Resection	Histology	>1 g	Plus exome tests, large immunohistology panels, and RNA tests (−70°C)