B-7 family of receptor ligands expressed by antigen presenting cells and various malignancies: CD cluster derivation; B7.1 known as CD80; B7.2 known as CD86; CD-28 and CD-152 present on T-naïve cells; ICOS inducible costimulatory ligand; (+) with and (−) without; CD152 also known as CTLA4 cytotoxic T lymphocytes antigen-4; PD-1 programmed death-1 also known as CD279; PD-L1 programmed death-ligand 1 known as B7-H1 or CD274; PD-L2 programmed death-ligand 2, known as CD273 or B7-DC B-7 dendritic cell; IFN-γ interferon gamma; IL-2 interleukin 2; Ref reference.
|B-7 family molecules||CD-designation||Major ligands on immune cells||Role immunity activation versus immune suppression||Malignancies expressing B-7 molecules||Ref|
|B7.1||CD80||CD28; CTLA4 (CD152)||(+) 2nd signal activation (−) second signal anergy||CD-80 on acute myeloid leukemia cells|||
|B7.2||CD86||CD28; CTLA4 (CD152)||(+) 2nd signal activation (−) second signal anergy||CD-86 on chronic lymphatic leukemia cells |||
|B7-H1 (PD-L1)||CD274||PD-1 (CD279)||Ligating PD-1 on T-cells suppresses CD8+ response||None|||
|B7-H2; B7-H3; B7-H6; ICOS ||CD275||CD278||Immune suppression||Dendritic cells infiltrating malignancies; cancer cells: hematologic malignancies, breast, gastrointestinal, lung, melanoma, bladder, and genitourinary cancers|||
|PD-L2 B7-DC||CD273||PD-1 (CD279)||Immune suppression reduces IL-2 and IFN-γ secretion, decreases proliferation and cytotoxicity, and induces apoptosis in activated T-cells||Primary mediastinal (thymic) large B-cell lymphoma|||