Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients

Table 4

Univariate and multivariate Cox regression analysis of possible prognostic variables and parameters that correlate with overall survival.

		Univariate analysis		Multivariate analysis
		Hazard ratio for death (95% confidence interval)	value	Hazard ratio for death (95% confidence interval)	value
Gender	Female	1 ref.		1 ref.
	Male	1.659 (0.630–4.368)	0.305	1.647 (0.524–5.180)	0.393
Location of tumor	Rectum	1 ref.		1 ref.
	Colon	1.418 (0.524–3.836)	0.492	1.555 (0.480–5.031)	0.461
Differentiation	Well	1 ref.		1 ref.
	Moderately	0.700 (0.234–2.091)	0.523	0.756 (0.221–2.587)	0.656
	Poorly	0.546 (0.147–2.031)	0.367	0.375 (0.076–1.840)	0.227
TNM stage	I	1 ref.		1 ref.
	II	0.561 (0.103–3.065)	0.505	0.621 (0.097–3.969)	0.614
	III	0.758 (0.379–8.142)	0.471	3.848 (0.612–24.192)	0.151
	IV	4.277 (0.599–30.522)	0.147	10.087 (0.803–126.629)	0.073
Family history	No	1 ref.		1 ref.
	Yes	0.672 (0.256–1.768)	0.421	0.746 (0.210–2.655)	0.651
Adjuvant therapy	No	1 ref.		1 ref.
	Yes	1.224 (0.430–3.482)	0.705	0.274 (0.063–1.195)	0.085
MSI results	MSS	1 ref.		1 ref.
	MSI-L	0.915 (0.251–3.336)	0.893	2.105 (0.584–7.580)	0.255
	MSH	2.026 (0.635–6.462)	0.233	0.512 (0.094–2.797)	0.440
Metastases	No	1 ref.		1 ref.
	Yes	0.392 (0.145–1.061)	0.065	2.799 (0.707–11.084)	0.143
Age of diagnosis	<50	1 ref.		1 ref.
	>50	0.723 (0.274–1.907)	0.512	2.240 (0.546–9.182)	0.263