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Journal of Oncology
Volume 2016, Article ID 3531274, 8 pages
Research Article

Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma

1Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil
2Department of Pathology and Forensic Sciences, University Hospital and School of Medicine of Santiago de Compostela, Santiago de Compostela, 15706 Galicia, Spain
3Faculty of Medicine and Dentistry, Institute of Research of Santiago de Compostela (IDIS), Clinical Hospital University of Santiago, Santiago de Compostela, 15782 A Coruña, Spain
4Department of Computing, Faculty of Sciences, São Paulo State University (UNESP), 17033-360 Bauru, SP, Brazil
5Pathology Division, Adolfo Lutz Institute, 01246-902 São Paulo, SP, Brazil
6Department of Community Dentistry, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, Brazil
7Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, 01509-010 São Paulo, SP, Brazil

Received 16 December 2015; Revised 1 February 2016; Accepted 10 February 2016

Academic Editor: Thomas R. Chauncey

Copyright © 2016 Denise Tostes Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with β2-AR expression was verified by the chi-square test or Fischer’s exact test. To verify the correlation of β2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson’s correlation coefficient test was applied. Results. The expression of β2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (; ). The immunohistochemical distribution of β2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (), simultaneous alcohol and tobacco consumption (), and T stage (). Conclusions. The correlation of β2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive.