Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma
Table 1
Association between clinical parameters and β2-AR expression in 62 patients with oral squamous cell carcinoma.
Variable
Beta-2 adrenergic receptor
Tumor-free margin
Invasive tumor front
Weak ()
Moderate/strong ()
Weak/negative ()
Moderate/strong ()
(%)
(%)
(%)
(%)
Gender
Male
8 (66.7)
44 (88)
0.091
31 (86.1)
21 (80.8)
0.729
Female
4 (33.3)
6 (12)
5 (13.9)
5 (19.2)
Ethnic group
White
10 (83.3)
45 (90)
0.612
33 (91.7)
22 (84.6)
0.439
Not white
2 (16.7)
5 (10)
3 (8.3)
4 (15.4)
Age
≤58 years
8 (66.7)
25 (50)
0.299
22 (61.1)
11 (42.3)
0.143
>58 years
4 (33.3)
25 (50)
14 (38.9)
15 (57.7)
Tobacco#
Yes
11 (100)
42 (93.3)
0.999
31 (100)
22 (88)
0.083
No
0 (0)
3 (6.7)
0 (0)
3 (12)
Alcohol
Yes
10 (90.9)
32 (69.6)
0.256
27 (84.4)
15 (60)
0.038
No
1 (9.1)
14 (30.4)
5 (15.6)
10 (40)
Tobacco + alcohol
Yes
10 (90.9)
29 (64.4)
0.144
26 (83.9)
13 (52)
0.010
No
1 (9.1)
16 (35.6)
5 (16.1)
12 (48)
T stage
T1/T2
6 (50)
28 (56)
0.708
15 (41.7)
19 (73.1)
0.014
T3/T4
6 (50)
22 (44)
21 (58.3)
7 (26.9)
N stage
N+
6 (50)
24 (48)
0.901
18 (50)
12 (46.2)
0.765
N0
6 (50)
26 (52)
18 (50)
14 (53.8)
Clinical stage
II
3 (25)
16 (32)
0.74
9 (25)
10 (38.5)
0.257
III/IV
9 (75)
34 (68)
27 (75)
16 (61.5)
Recurrence
Yes
6 (50)
20 (40)
0.528
17 (47.2)
9 (34.6)
0.321
No
6 (50)
30 (60)
19 (52.8)
17 (65.4)
Metastases
Yes
0 (0)
1 (2)
0.999
0 (0)
1 (3.8)
0.419
No
12 (100)
49 (98)
36 (100)
25 (96.2)
Second primary tumor
Yes
1 (8.3)
8 (16)
0.675
5 (13.9)
4 (15.4)
0.999
No
11 (91.7)
42 (84)
31 (86.1)
22 (84.6)
: number of cases; : value obtained by chi-square test or Fisher’s exact test; excluding patients with lost records; local and/or regional recurrence; statistically significant result.
