Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation

Figure 4

Hyaluromycin inhibited phosphorylation of ribosomal protein S6. We examined the simultaneous detection of 18 important and well-characterized signaling molecules when phosphorylated or cleaved in PDAC cells by PathScan® Intracellular Signaling Array Kit. Treatment with hyaluromycin at 50 μM for 24 hours resulted in decreased phosphorylation (at Ser235/236) of ribosomal protein S6 in PDAC cell lines.