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Journal of Oncology
Volume 2017, Article ID 6095205, 9 pages
Research Article

The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma

1Department of Pathology, Faculty of Medicine, Zagazig University, Sharkia, Egypt
2Department of Medical Oncology, Faculty of Medicine, Zagazig University, Sharkia, Egypt
3Department of Urology, Faculty of Medicine, Zagazig University, Sharkia, Egypt
4Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Correspondence should be addressed to Rasha Haggag; moc.oohay@hmmr_rd

Received 17 July 2016; Revised 15 October 2016; Accepted 18 October 2016; Published 17 January 2017

Academic Editor: Akira Hara

Copyright © 2017 Ola A. Harb et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member which can mediate carcinogenesis through intracellular signaling. Methods. To assess their prognostic role; NEDD9 and p38 protein were evaluated in sections from 50 paraffin blocks of TCC. Results. The high expressions of NEDD9 and p38 protein were significantly associated with grade, stage, distant metastasis (), number of tumors, lymph node metastasis, and tumor size (, 0.002; 0.018, <0.001; and 0.004, 0.007, respectively). High NEDD9 and p38 detection had a worse 3-year OS ( and <0.001, respectively). By multivariate analysis the NEDD9 and p38 protein expression levels and various clinicopathological criteria including gender, grade, stage of the tumor, and regional lymph node involvement were independent prognostic parameters of TCC of the urinary bladder patients’ outcome. Conclusion. NEDD9 and p38 protein expressions were poor prognostic markers of TCC.