Journal of Oncology / 2017 / Article / Tab 3 / Review Article
Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems Table 3 Phytochemicals combined with first-line antitumor drugs and their study in clinical trials. Nanocarriers used to enhance bioefficacy of codelivery are also shown.
Phytochemical Codelivered antitumor agent In vitro /in vivo Clinical trial Phase of study Ref. Ellagic acid 5-Fluorouracil Colon — — [279 ] Vinorelbine — Hormone refractory prostate cancer Completed [167 ] α -DifluoromethylornithineColon — — [280 ] (−)-Epigallocatechin-3-gallate (EGCG) Tamoxifen + sulindac Lung — — [281 ] Sulindac Intestinal — — [281 ] Genistein Tamoxifen Breast — — [282 ] Gemcitabine hydrochloride Pancreas Breast Completed [283 –285 ] Osteosarcoma Decitabine — Pediatric solid tumors, leukemia Recruiting [286 ] Decitabine — Non-small cell lung Completed [287 ] Interleukin-2 (high-dose) — Kidney cancer Completed [288 ] Melanoma 5-Fluorouracil Colon — — [289 ] Docetaxel Prostate — — [290 ] Lung Breast Pancreas Doxorubicin Prostate — — [290 ] Lung Breast Pancreas Cisplatin Ovarian — — [290 , 291 ] Prostate Lung Breast Pancreas Erlotinib — Pancreas Completed [292 ] Erlotinib + gemcitabine Pancreas Pancreas Completed [293 , 294 ] Luteolin Celecoxib Breast — — [295 ] Quercetin Docetaxel Prostate — — [296 ] 5-Fluorouracil Esophageal — — [297 –299 ] Colorectal Liver Sulindac Colorectal Colon Completed [300 ] Tamoxifen Breast — — [301 ] Paclitaxel Liver — — [302 ] Resveratrol Rapamycin Breast — — [303 ] Doxorubicin Breast — — [304 ] Temozolomide Glioma — — [305 ] 5-Fluorouracil Colon [306 ] Mitomycin Colorectal — — [307 ] Curcumin Irinotecan Colorectal Colorectal Active [308 , 309 ] Folfox Colon Active [310 ] Sulindac Lung Colorectal Completed [224 , 311 ] Capecitabine Rectal Active [311 ] 5-Fluorouracil Colorectal — — [312 ] Dasatinib Colon — — [313 ] Paclitaxel Breast [314 ] Celecoxib Colon [315 ] Gemcitabine Lung — — [316 ] Genistein Prostate — — [317 ] Lycopene Docetaxel Prostate Adenocarcinoma of the prostate Active [318 , 319 ]
