Journal of Oncology / 2017 / Article / Tab 5 / Review Article
Improving In Vivo Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems Table 5 Overview of lipid-based delivery systems to administer phytochemicals by oral route.
Active ingredient Lipid-based formulation Effect of formulation Ref. Vinorelbine Liposomes Reduced side effects and increased circulation half-life. [94 ] Improved therapeutic effect in vivo . Gypenoside Activated in vitro immune response in macrophages. [335 ] Curcumin Improved pharmacokinetics and oral bioavailability in vivo . [329 , 336 ] 3-EGCG Enhanced in vitro antitumor activity. [337 ] Brucine Improved absorption and oral bioavailability, enhanced targeting, and reduced side effects in vivo . [338 , 339 ] Quercetin Phytosome Enhanced membrane permeability, sustained and controlled release. Enhanced absorption, oral bioavailability, and bioefficacy. Kaempferol [101 ] Isorhamnetin Silybin [98 , 99 ] 3-EGCG [102 ] Quercetin [100 ] β -ElemeneMicroemulsions Increased water solubility and permeability and improved oral bioavailability. [131 ] Hydroxysafflor yellow A [130 ] Puerarin [127 , 340 ] Baicalin SEDS Enhanced stability, oral bioavailability, and targeting effects in vitro and in vivo . [134 ] Curcumin SMEDS Enhanced stability, oral bioavailability, and targeting effects in vitro and in vivo . [341 ] Indirubin [88 ] Hydroxysafflor yellow A [143 , 144 ] Gentiopicrin [341 ] Lutein [342 ] Apigenin [343 ] Nobiletin [137 ] Oridonin [139 ] Silymarin [140 ] Puerarin [344 ] Hesperidin [345 ] Berberine hydrochloride (BBH) [346 ] Morin SNEDS Enhanced stability, oral bioavailability, and targeting effects in vitro and in vivo . [145 ] Curcumin [347 ] Lutein [146 ] Oleanolic acid [348 ] Vinpocetine [349 ] Puerarin SLNs Improved absorption and oral bioavailability and reduced side effects (irritation of GI mucous membrane) in vivo . [120 , 121 ] Triptolide [350 ] Cantharidin [351 ] Resveratrol [352 ] Silymarin NLCs Increased absorption and oral bioavailability in vivo . Enhanced in vitro and in vivo antitumor activity. [123 ] Tripterine [124 ] Curcumin