Journal of Oncology / 2018 / Article / Tab 2

Research Article

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma

Table 2

Univariate and multivariate analyses of the new prognostic factors for progression-free survival.

VariablesUnivariableMultivariable model 1Multivariable model 2
N (event)HR (95% CI)p-valueHR (95% CI)p-valueHR (95% CI)p-value

Age ≥55 years101 (76)0.79 (0.56-1.13)0.204
Female gender34 (28)1.07 (0.69-1.65)0.770
Metachronous type61 (50)0.64 (0.44-0.92)0.015
Nephrectomy89 (72)0.48 (0.33-0.70)<.0010.48 (0.32-0.71)<.0010.48 (0.33-0.71)<.001
Body mass index145 (121)0.98 (0.92-1.04)0.500
KPS≤8012 (11)1.10 (0.59-2.08)0.760
DFI≤1year106 (87)1.76 (1.20-2.58)0.004
mMSKCC, favorable48 (42)1(0.287)
    intermediate74 (59)1.38 (0.92-2.06)0.121
    poor12 (10)1.34 (0.66-2.71)0.415
Heng, favorable14 (12)1(0.021)
   intermediate94 (77)2.00 (1.08-3.73)0.029
   poor24 (20)2.84 (1.36-5.92)0.006
Lung metastasis113 (93)0.79 (0.53-1.16)0.228
Liver metastasis33 (26)1.23 (0.79-1.90)0.366
Bone metastasis54 (47)0.92 (0.64-1.32)0.652
Brain metastasis18 (16)1.30 (0.77-2.22)0.329
Hb, M<13, F<11.590 (70)1.30 (0.91-1.86)0.148
Platelet ≥400K19 (15)1.95 (1.12-3.39)0.018
Neutrophil ≥750028 (21)1.60 (0.99-2.57)0.054
Lymphocyte≥150060 (47)1.37 (0.95-1.98)0.097
NLR152 (125)1.03 (1.00-1.06)0.0261.04 (1.00-1.07)0.029
LDH ≥30013 (12)1.72 (0.93-3.19)0.084
Corrected Calcium ≥1011 (9)0.93 (0.46-1.85)0.832
Albumin <3.523 (16)1.78 (1.04-3.07)0.037
Alkaline phosphatase ≥10450 (42)1.40 (0.96-2.07)0.085
AST≥4012 (11)2.56 (1.36-4.84)0.0041.96 (1.03-3.76)0.042
ALT≥4018 (15)1.26 (0.73-2.18)0.399
De Retis ratio148 (122)1.19 (0.97-1.45)0.096

KPS, Karnofsky performance status score; DFI, disease-free interval; Hb, hemoglobin; NLR, neutrophil-to-lymphocyte ratio; LDH, lactate dehydrogenase; AST, aspartate transaminase; ALT, alanine transaminase; HR, hazard ratio; CI, confidence interval.
Multivariable model 1 (uni p-value ≤0.15 without LDH) used with metachronous type, nephrectomy, DFI<1, Hb, platelet, neutrophil, lymphocyte, albumin, Alkaline phosphatase, AST.
Multivariable model 2 (uni p-value ≤0.15 without LDH) used with metachronous type, nephrectomy, DFI<1, Hb, platelet, albumin, Alkaline phosphatase, NLR, de retis ratio.

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