The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma

Table 2

Univariate and multivariate analyses of the new prognostic factors for progression-free survival.

Variables	Univariable			Multivariable model 1		Multivariable model 2
	N (event)	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Age ≥55 years	101 (76)	0.79 (0.56-1.13)	0.204
Female gender	34 (28)	1.07 (0.69-1.65)	0.770
Metachronous type	61 (50)	0.64 (0.44-0.92)	0.015
Nephrectomy	89 (72)	0.48 (0.33-0.70)	<.001	0.48 (0.32-0.71)	<.001	0.48 (0.33-0.71)	<.001
Body mass index	145 (121)	0.98 (0.92-1.04)	0.500
KPS≤80	12 (11)	1.10 (0.59-2.08)	0.760
DFI≤1year	106 (87)	1.76 (1.20-2.58)	0.004
mMSKCC, favorable	48 (42)	1	(0.287)
intermediate	74 (59)	1.38 (0.92-2.06)	0.121
poor	12 (10)	1.34 (0.66-2.71)	0.415
Heng, favorable	14 (12)	1	(0.021)
intermediate	94 (77)	2.00 (1.08-3.73)	0.029
poor	24 (20)	2.84 (1.36-5.92)	0.006
Lung metastasis	113 (93)	0.79 (0.53-1.16)	0.228
Liver metastasis	33 (26)	1.23 (0.79-1.90)	0.366
Bone metastasis	54 (47)	0.92 (0.64-1.32)	0.652
Brain metastasis	18 (16)	1.30 (0.77-2.22)	0.329
Hb, M<13, F<11.5	90 (70)	1.30 (0.91-1.86)	0.148
Platelet ≥400K	19 (15)	1.95 (1.12-3.39)	0.018
Neutrophil ≥7500	28 (21)	1.60 (0.99-2.57)	0.054
Lymphocyte≥1500	60 (47)	1.37 (0.95-1.98)	0.097
NLR	152 (125)	1.03 (1.00-1.06)	0.026			1.04 (1.00-1.07)	0.029
LDH ≥300	13 (12)	1.72 (0.93-3.19)	0.084
Corrected Calcium ≥10	11 (9)	0.93 (0.46-1.85)	0.832
Albumin <3.5	23 (16)	1.78 (1.04-3.07)	0.037
Alkaline phosphatase ≥104	50 (42)	1.40 (0.96-2.07)	0.085
AST≥40	12 (11)	2.56 (1.36-4.84)	0.004	1.96 (1.03-3.76)	0.042
ALT≥40	18 (15)	1.26 (0.73-2.18)	0.399
De Retis ratio	148 (122)	1.19 (0.97-1.45)	0.096

KPS, Karnofsky performance status score; DFI, disease-free interval; Hb, hemoglobin; NLR, neutrophil-to-lymphocyte ratio; LDH, lactate dehydrogenase; AST, aspartate transaminase; ALT, alanine transaminase; HR, hazard ratio; CI, confidence interval.
Multivariable model 1 (uni p-value ≤0.15 without LDH) used with metachronous type, nephrectomy, DFI<1, Hb, platelet, neutrophil, lymphocyte, albumin, Alkaline phosphatase, AST.
Multivariable model 2 (uni p-value ≤0.15 without LDH) used with metachronous type, nephrectomy, DFI<1, Hb, platelet, albumin, Alkaline phosphatase, NLR, de retis ratio.