Journal of Oncology

Research Article

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma

Table 3

Univariate and multivariate analyses of overall survival using the new prognostic factors.


Variables	Univariable			Multivariable 1		Multivariable 2
Variables	N (event)	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value

Age ≥55 years	101 (81)	0.92 (0.64-1.32)	0.635
Female gender	34 (33)	1.38 (0.92-2.06)	0.117
Metachronous type	61 (48)	0.48 (0.33-0.69)	<.001
Nephrectomy	89 (70)	0.34 (0.23-0.50)	<.001	0.37 (0.24-0.55)	<.001	0.38 (0.25-0.56)	<.001
Body mass index	145 (118)	0.96 (0.90-1.02)	0.159
KPS≤80	12 (10)	1.02 (0.53-1.96)	0.955
DFI≤1year	106 (88)	2.04 (1.40-2.99)	<.001
mMSKCC, favorable	48 (33)	1	(0.003)
intermediate	74 (64)	1.77 (1.16-2.70)	0.009
poor	12 (12)	2.83 (1.45-5.54)	0.002
Heng, favorable	14 (7)	1	<.001
intermediate	94 (79)	3.11 (1.42-6.78)	0.004
poor	24 (21)	6.46 (2.70-15.46)	<.001
Lung metastasis	113 (91)	0.76 (0.52-1.11)	0.152
Liver metastasis	33 (32)	1.92 (1.28-2.89)	0.002	1.88 (1.21-2.94)	0.005
Bone metastasis	54 (48)	1.12 (0.78-1.61)	0.533
Brain metastasis	18 (13)	0.98 (0.55-1.75)	0.955
Hb, M<13, F<11.5	90 (81)	2.04 (1.41-2.94)	<.001	1.83 (1.23-2.71)	0.003	1.71 (1.16-2.51)	0.007
Platelet ≥400	19 (16)	2.51 (1.45-4.34)	0.001
Neutrophil ≥7500	28 (24)	2.17 (1.37-3.42)	0.001	2.58 (1.55-4.30)	<.001
Lymphocyte≥1500	60 (53)	1.71 (1.19-2.45)	0.003
NLR	152 (125)	1.06 (1.03-1.09)	<.001			1.07 (1.04-1.11)	<.001
LDH ≥300	13 (11)	1.37 (0.72-2.58)	0.338
Corrected Calcium ≥10	11 (11)	1.73 (0.92-3.24)	0.087
Albumin <3.5	23 (21)	3.77 (2.28-6.22)	<.001
Alkaline phosphatase≥104	50 (43)	1.83 (1.23-2.70)	0.003	1.63 (1.08-2.45)	0.019	1.73 (1.16-2.58)	0.008
AST≥40	12 (12)	3.60 (1.95-6.65)	<.001
ALT≥40	101 (81)	0.92 (0.64-1.32)	0.635
De Retis ratio	34 (33)	1.38 (0.92-2.06)	0.117			1.34 (1.09-1.64)	0.006

KPS, Karnofsky performance score; DFI, disease-free interval; Hb, hemoglobin; NLR, neutrophil-to-lymphocyte ratio; LDH, lactate dehydrogenase; AST, aspartate transaminase; ALT, alanine transaminase; HR, hazard ratio; CI, confidence interval.
Multivariable 1 (uni p-value ≤0.15 without LDH) used with gender, metachronous type, nephrectomy, DFI<1, liver mets, Hb, platelet, neutrophil, Lymphocyte, corrected ca, Alkaline phosphatase, AST.
Multivariable 2 (uni p-value ≤0.15 without LDH) used with gender, metachronous type, nephrectomy, DFI<1, liver mets, Hb, platelet, corrected ca, Alkaline phosphatase, NLR, de retis ratio.