Journal of Oncology / 2018 / Article / Tab 3

Research Article

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma

Table 3

Univariate and multivariate analyses of overall survival using the new prognostic factors.

VariablesUnivariableMultivariable 1Multivariable 2
N (event)HR (95% CI)p-valueHR (95% CI)p-valueHR (95% CI)p-value

Age ≥55 years101 (81)0.92 (0.64-1.32)0.635
Female gender34 (33)1.38 (0.92-2.06)0.117
Metachronous type61 (48)0.48 (0.33-0.69)<.001
Nephrectomy89 (70)0.34 (0.23-0.50)<.0010.37 (0.24-0.55)<.0010.38 (0.25-0.56)<.001
Body mass index145 (118)0.96 (0.90-1.02)0.159
KPS≤8012 (10)1.02 (0.53-1.96)0.955
DFI≤1year106 (88)2.04 (1.40-2.99)<.001
mMSKCC, favorable48 (33)1(0.003)
   intermediate74 (64)1.77 (1.16-2.70)0.009
   poor12 (12)2.83 (1.45-5.54)0.002
Heng, favorable14 (7)1<.001
   intermediate94 (79)3.11 (1.42-6.78)0.004
   poor24 (21)6.46 (2.70-15.46)<.001
Lung metastasis113 (91)0.76 (0.52-1.11)0.152
Liver metastasis33 (32)1.92 (1.28-2.89)0.0021.88 (1.21-2.94)0.005
Bone metastasis54 (48)1.12 (0.78-1.61)0.533
Brain metastasis18 (13)0.98 (0.55-1.75)0.955
Hb, M<13, F<11.590 (81)2.04 (1.41-2.94)<.0011.83 (1.23-2.71)0.0031.71 (1.16-2.51)0.007
Platelet ≥40019 (16)2.51 (1.45-4.34)0.001
Neutrophil ≥750028 (24)2.17 (1.37-3.42)0.0012.58 (1.55-4.30)<.001
Lymphocyte≥150060 (53)1.71 (1.19-2.45)0.003
NLR152 (125)1.06 (1.03-1.09)<.0011.07 (1.04-1.11)<.001
LDH ≥30013 (11)1.37 (0.72-2.58)0.338
Corrected Calcium ≥1011 (11)1.73 (0.92-3.24)0.087
Albumin <3.523 (21)3.77 (2.28-6.22)<.001
Alkaline phosphatase≥10450 (43)1.83 (1.23-2.70)0.0031.63 (1.08-2.45)0.0191.73 (1.16-2.58)0.008
AST≥4012 (12)3.60 (1.95-6.65)<.001
ALT≥40101 (81)0.92 (0.64-1.32)0.635
De Retis ratio34 (33)1.38 (0.92-2.06)0.1171.34 (1.09-1.64)0.006

KPS, Karnofsky performance score; DFI, disease-free interval; Hb, hemoglobin; NLR, neutrophil-to-lymphocyte ratio; LDH, lactate dehydrogenase; AST, aspartate transaminase; ALT, alanine transaminase; HR, hazard ratio; CI, confidence interval.
Multivariable 1 (uni p-value ≤0.15 without LDH) used with gender, metachronous type, nephrectomy, DFI<1, liver mets, Hb, platelet, neutrophil, Lymphocyte, corrected ca, Alkaline phosphatase, AST.
Multivariable 2 (uni p-value ≤0.15 without LDH) used with gender, metachronous type, nephrectomy, DFI<1, liver mets, Hb, platelet, corrected ca, Alkaline phosphatase, NLR, de retis ratio.

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