Research Article
Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA
Table 2
Comparison of vital signs and laboratory findings of 25 case patients and of 79 control patients with neutropenic fever in the emergency department.
| | Characteristics | Total (n = 104) | Case (n = 25) | Control (n = 79) | P value |
| | Vital signs on presentation | | | | | | SBP, mm Hg | 119.1 ± 21.6 | 106.7 ± 24.6 | 122 (110-135) | 0.001∗∗ | | DBP, mm Hg | 70.8 ± 14.3 | 62.0 ± 14.1 | 73.6 ± 13.3 | 0.0003∗∗∗ | | PR, beats/min | 110 (92-128) | 119.7 ± 18.9 | 106.0 (88.5-124.7) | 0.013∗ | | RR, breaths/min | 18 (18-20) | 20 (18-24) | 18 (18-20) | 0.252 | | Body temperature, °C | 38.4 (38-38.9) | 38.5 (38.0-38.1) | 38.3 (38.0-38.7) | 0.649 | | Saturation, % | 97 (96-98) | 96.0 (93.1-97.0) | 97 (96-98) | 0.001∗∗ |
| | qSOFA | 0.49 ± 0.63 | 0.88 ± 0.78 | 0.36 ± 0.53 | 0.0003∗∗∗ |
| | Complete blood cell counts | | | | | | Leukocyte count, x109cells/mL | 1120(615-1570) | 710 (462-1473) | 1170 (702-1625) | 0.056 | | ANC | 205 (84-567) | 174 (67-335) | 222 (101-666) | 0.087 | | Profound neutropenia, no. (%) | 29 (28) | 10 (25) | 19 (24) | 0.123 | | Hemoglobin, g/dL | 9.6 ± 2.1 | 8.1 ± 2.2 | 10.3 (9.1-11) | < 0.0001∗∗∗ | | Platelet, x103/μl | 95 (52-178) | 52 (27-114) | 123 (68-188) | 0.002∗∗ |
| | Other laboratory findings | | | | | | CRP, mg/dL | 5.5 (3-12.6) | 10.2 (6.5-17.7) | 4.0 (2.2-9.5) | < 0.0001∗∗∗ | | Lactic acid, mmol/L | 1.9 (1.4-2.5) | 2.15 (1.4-5.0) | 1.75 (1.4-2.35) | 0.126 | | Glucose, mg/dL | 131 (112-161) | 159 ± 55.4 | 129 (112-147) | 0.106 | | Total bilirubin, mg/dL | 0.7 (0.5-1.1) | 0.9 (0.5-1.2) | 0.6 (0.4-0.9) | 0.029∗ | | Creatinine, mg/dl | 0.77 (0.62-0.96) | 0.97 (0.74-2.01) | 0.72 (0.62-0.89) | 0.001∗∗ | | Albumin, g/dL | 3.5 (3.2-3.8) | 3.1 ± 0.4 | 3.7 (3.3-3.8) | 0.0004∗∗∗ |
| | Arterial blood gas | | | | | | pH | 7.47 (7.44-7.49) | 7.46(7.43-7.49) | 7.47 ± 0.03 | 0.124 | | PCO2, mm Hg | 31.5 ± 5.7 | 30.6 ± 8.1 | 31.9 ± 4.6 | 0.334 | | PO2, mm Hg | 81.2 (73.7-94.8) | 78.7 (69.6-95.9) | 81.6 (78.8 -91.4) | 0.402 | | HC, mmol/L | 22.7 (20.8-24.9) | 20.2 ± 4.8 | 23.4 ± 2.8 | 0.0002∗∗∗ | | SpO2, mm Hg | 96.7 (95.3-97.7) | 96.2 (94-97.5) | 96.8 (95.5-97.7) | 0.150 |
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<0.05, ∗∗p<0.01 ∗∗∗p<0.001: significant change from baseline values. qSOFA: quick sepsis-related organ failure assessment; ANC: absolute neutrophil count; CRP: C-reactive protein. |
