Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA
Table 3
Comparison of source of infection and treatment outcome of 25 case patients and of 79 control patients with neutropenic fever in the emergency department.
Characteristics
Total (n = 104)
Case (n = 25)
Control (n = 79)
P value
Source of infection, no. (%)
26 (25)
13 (52)
13 (16)
0.0004∗∗∗
Respiratory tract
9 (9)
3 (12)
6 (8)
0.446
Urinary tract
6 (6)
1 (4)
5 (6)
1.0
Gastrointestinal tract
2 (2)
1 (4)
1 (1)
0.424
Hepatobiliary tract
3 (3)
1 (4)
2 (3)
0.565
Skin and soft tissue
58 (26)
6 (24)
52 (66)
0.0003∗∗∗
Unknown
Bacteremia, no (%)
12 (12)
6 (24)
6 (8)
0.035∗
Combination therapy, no (%)
21 (20)
8 (32)
13 (16)
0.093
Time from ED visit to antibiotics, min
107 (83-135)
101 (85-119)
110.5 (83-139)
0.324
Inappropriateness of antibiotics, no (%)
1 out of 7
1 out of 11
1.0
Use of G-CSF, no. (%)
58 (56)
14 (56)
44 (56)
0.978
Use of vasopressor, no. (%)
16 (15)
14 (56)
2 (3)
< 0.0001∗∗∗
Intubation, no. (%)
6 (6)
6 (24)
0
ICU care, no. (%)
20 (19)
20 (80)
0
DNR order, no. (%)
7 (28)
0
Hospital days
7 (5-12)
11 (6.7-22)
7 (4-10.7)
0.010∗
In-hospital death, no (%)
12 (12)
12 (48)
0
<0.05, ∗∗p<0.01 ∗∗∗p<0.001: significant change from baseline values. ED: emergency department; G-CSF: granulocyte-colony stimulating factor; ICU: intensive care unit; DNR: do not resuscitate.
