Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer

Figure 4

(a) Bar graphs obtained by densitometric analysis of western blot data of IRS-4, IGF-1 signalling axis proteins, and proliferation and apoptosis biomarkers in human colorectal carcinoma tissues (T) (n=20) and matched adjacent normal colorectal tissues (N) (n=20). Results represent the mean ± SD. Levels of significance: p<0.05; p<0.01. (b) Pearson’s correlation coefficient between caspase 3 and PARP fragments, p53 fragments and GSK-3 fragments and between p53 fragments and GSK-3 fragments of CRC and MANC tissues of the 20 patients studied. The black and white points correspond to MANC and CRC tissues, respectively. N = MANC tissue. OD = optical density. A.U. = arbitrary units.

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