Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru
Table 3
Effect of maternal age in childhood solid cancers development.
Diagnosis
Maternal age
N
Unadjusted OR
CI 95
Adjusted OR
CI 95
Brain tumor
All ages
62
p-value=0.99a
p-value=0.97
<20
5
1.06
0.32-3.46
1.06
0.71-1.55
20-24
16
2.06
0.80-5.29
1.92
0.27-4.16
25-29b
14
1
1
30-34
18
2.10
0.83-5.27
1.42
0.53-3.08
>35
9
1.26
0.44-3.55
0.88
0.26-2.97
Non-Hodgkin lymphoma
All ages
43
p-value=0.56
p-value=0.80
<20
1
0.33
0.03-3.08
0.45
0.34-4.50
20-24
11
1.29
0.47-3.51
1.53
0.54-4.30
25-29b
13
1
1
30-34
13
1.69
0.63-4.48
1.61
0.50-4.57
>35
5
1.00
0.29-3-37
0.91
0.22-3.81
Osteosarcoma
All ages
42
p-value=0.019
p-value=0.054
<20
3
0.85
0.34-2.56
0.60
0.40-3.09
20-24
16
0.70
0.24-2.04
0.58
0.16-2.08
25-29b
10
1
1
30-34
8
1.38
0.52-3.64
0.99
0.62-2.30
>35
5
1.91
1.12-3.09
1.35
0.81-2.33
Wilms tumor
All ages
35
p-value=0.954
p-value=0.346
<20
1
-
-
20-24
10
2.47
0.73-8.39
2.76
0.75-10.17
25-29b
5
1
1
30-34
9
3.71
0.96-14.30
3.18
0.73-13.83
>35
10
1.52
0.43-5.39
0.91
0.22-3.73
Ewing’s sarcoma
All ages
24
p-value=0.713
p-value=0.543
<20
2
0.78
0.11-5.26
0.65
0.07-5.35
20-24
7
1.24
0.32-4.76
1.51
0.31-7.37
25-29b
7
1
1
30-34
3
0.35
0-07-1.60
2.73
0.51-1.33
>35
5
1.46
0.26-8.11
1.05
0.18-6.06
Soft tissue sarcoma
All ages
24
p-value=0.567
p-value=0.33
<20
0
20-24
6
1.58
0.31-8.01
1.40
0.26-7.39
25-29b
7
1
1
30-34
6
0.92
0.24-3.47
1.45
0.29-7.09
>35
5
2.04
0.47-8.78
1.59
0.45-8.59
Gonadal germinal tumor
All ages
21
p-value: 0.15
p-value=0.54
<20
1
20-24
8
2.03
0.33-12.38
2.45
0.28-20.88
25-29b
3
1
1
30-34
6
1.92
0.25-14.3
1.37
0.17-10.94
>35
3
0.85
0.11-6.12
0.76
0.09-6.37
Retinoblastoma
All ages
16
p-value=0.04
p-value=0.037
<20
0
20-24
5
2.30
0.29-4.83
0.26
0.20-3.53
25-29b
3
1
1
30-34
3
1.00
0.47-5.28
1.09
0.41-4.07
>35
5
1.51
0.67-8.19
1.21
1.09-6.08
Hepatoblastoma
All ages
16
p-value= 0.587
p-value=0.07
<20
1
0.54
0.03-8.10
-
20-24
2
0.55
0.05-5.67
1.02
0.07-14-12
25-29b
3
1
1
30-34
4
0.84
0.14-4.89
1.91
0.23-15.31
>35
6
1.27
0.25-6.31
4.35
0.31-60.38
Hodgkin lymphoma
All ages
14
p-value=0.192
p-value=0.196
<20
2
5.08
0.34-75.08
5.58
0.20-14.93
20-24
6
2.40
0.37-15.71
1.87
0.26-13.41
25-29b
2
1
1
30-34
4
2.89
0.35-23.39
1.03
0.08-13.10
>35
0
Neuroblastoma
All ages
12
p-value=0.898
p-value=0.51
<20
1
-
-
20-24
1
-
-
25-29b
5
1
1
30-34
4
0.66
0.054-8-07
1.91
0.24-15.10
>35
1
-
0.76
0.04-14.02
Adjusted by paternal age, number of siblings, and level of maternal and paternal education. Significant results are bolded. a denotes where age groups are taken to be continuous in all cancers. b denotes reference group.
